1-allyl-4-isobutoxy-2-oxo-cyclohex-3-enecarboxylic acid methyl ester

Base Information

• Chemical Name: 1-allyl-4-isobutoxy-2-oxo-cyclohex-3-enecarboxylic acid methyl ester
• CAS No.: 528885-73-6
• Molecular Formula: C₁₅H₂₂O₄
• Molecular Weight: 266.337
• Mol file: 528885-73-6.mol

Synonyms:1-allyl-4-isobutoxy-2-oxo-cyclohex-3-enecarboxylic acid methyl ester

Chemical Property of 1-allyl-4-isobutoxy-2-oxo-cyclohex-3-enecarboxylic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-allyl-4-isobutoxy-2-oxo-cyclohex-3-enecarboxylic acid methyl ester

There total 1 articles about 1-allyl-4-isobutoxy-2-oxo-cyclohex-3-enecarboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

methyl cyanoformate (17640-15-2) + 6-allyl-3-isobutoxycyclohex-2-en-1-one (40649-34-1) → 1-allyl-4-isobutoxy-2-oxo-cyclohex-3-enecarboxylic acid methyl ester (528885-73-6)

Guidance literature:

6-allyl-3-isobutoxycyclohex-2-en-1-one; With N,N,N,N,N,N-hexamethylphosphoric triamide; lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃; for 1h;

methyl cyanoformate; In tetrahydrofuran; at -78 ℃; for 0.5h;

DOI:10.1021/ol034027+

Reference yield:

1-allyl-4-isobutoxy-2-oxo-cyclohex-3-enecarboxylic acid methyl ester (528885-73-6) → (+/-)-4-oxo-1-(2-propenyl)-2-cyclohexene-1-methanol (436145-96-9)

Guidance literature:

1-allyl-4-isobutoxy-2-oxo-cyclohex-3-enecarboxylic acid methyl ester; With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 ℃; for 0.166667h;

With perchloric acid; In tetrahydrofuran; water; at 20 ℃; for 0.333333h;

DOI:10.1021/ol034027+

Reference yield:

1-allyl-4-isobutoxy-2-oxo-cyclohex-3-enecarboxylic acid methyl ester (528885-73-6) → (+/-)-4-methoxymethoxymethyl-4-(2-propenyl)cyclohex-2-en-1-one (436145-97-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: LiAlH₄ / tetrahydrofuran / 0.17 h / 0 °C

1.2: HClO₄ / tetrahydrofuran; H₂O / 0.33 h / 20 °C

2.1: 37.7 g / i-Pr₂NEt / CH₂Cl₂ / 0 - 20 °C

With lithium aluminium tetrahydride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane;

DOI:10.1021/ol034027+

upstream raw materials:

methyl cyanoformate

6-allyl-3-isobutoxycyclohex-2-en-1-one

Downstream raw materials:

(+/-)-4-oxo-1-(2-propenyl)-2-cyclohexene-1-methanol

(+/-)-4-methoxymethoxymethyl-4-(2-propenyl)cyclohex-2-en-1-one

4-allyl-4-methoxymethoxymethyl-6-methyl-cyclohex-2-enone

4-allyl-4-benzyloxymethyl-cyclohex-2-enone