(3R,4S)-3,4-Diacetoxy-6-((E)-2-ethoxycarbonyl-vinyl)-3,4-dihydro-2H-pyridine-1-carboxylic acid benzyl ester

Base Information

Chemical Name:(3R,4S)-3,4-Diacetoxy-6-((E)-2-ethoxycarbonyl-vinyl)-3,4-dihydro-2H-pyridine-1-carboxylic acid benzyl ester
CAS No.:115710-39-9
Molecular Formula:C₂₂H₂₅NO₈
Molecular Weight:431.442
Hs Code.:

Synonyms:(3R,4S)-3,4-Diacetoxy-6-((E)-2-ethoxycarbonyl-vinyl)-3,4-dihydro-2H-pyridine-1-carboxylic acid benzyl ester

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Chemical Property of (3R,4S)-3,4-Diacetoxy-6-((E)-2-ethoxycarbonyl-vinyl)-3,4-dihydro-2H-pyridine-1-carboxylic acid benzyl ester

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Technology Process of (3R,4S)-3,4-Diacetoxy-6-((E)-2-ethoxycarbonyl-vinyl)-3,4-dihydro-2H-pyridine-1-carboxylic acid benzyl ester

There total 23 articles about (3R,4S)-3,4-Diacetoxy-6-((E)-2-ethoxycarbonyl-vinyl)-3,4-dihydro-2H-pyridine-1-carboxylic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 115710-38-8
4,5-di-O-acetyl-2,6-benzyloxycarbonylimino-2,3,6-trideoxy-aldehydo-D-erythro-hex-2-enose

: 1099-45-2
ethyl (triphenylphosphoranylidene)acetate

: 115710-39-9
(3R,4S)-3,4-Diacetoxy-6-((E)-2-ethoxycarbonyl-vinyl)-3,4-dihydro-2H-pyridine-1-carboxylic acid benzyl ester

Guidance literature:: In acetonitrile;
DOI:10.1016/S0040-4039(00)96576-6

Reference yield: 78.0%

: 115710-38-8
4,5-di-O-acetyl-2,6-benzyloxycarbonylimino-2,3,6-trideoxy-aldehydo-D-erythro-hex-2-enose

: 1099-45-2
ethyl (triphenylphosphoranylidene)acetate

: 115710-39-9,120293-94-9
(3R,4S)-3,4-Diacetoxy-6-((E)-2-ethoxycarbonyl-vinyl)-3,4-dihydro-2H-pyridine-1-carboxylic acid benzyl ester

Guidance literature:: In acetonitrile; for 1h; Heating;
DOI:10.1016/S0040-4020(01)89805-7

Reference yield:

: 17460-37-6
methyl 2-azido-4,6-O-benzylidene-2-deoxy-α-D-altropyranoside

: 115710-39-9,120293-94-9
(3R,4S)-3,4-Diacetoxy-6-((E)-2-ethoxycarbonyl-vinyl)-3,4-dihydro-2H-pyridine-1-carboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 9 steps

1: 76 percent / 20percent acetic acid / H₂O / 1 h / 80 °C

2: 63 percent / pyridine

3: 91 percent / H₂ / 10percent Pd/C / ethanol / 2327.2 Torr

4: 4.7 g / sodium acetate / ethanol / Heating

5: sodium bicarbonate / ethanol; H₂O / 2 h

6: 77 percent / hydrochloric acid / CHCl₃ / 9 h

7: pyridine

8: mercuric chloride, cadmium carbonate / acetone; H₂O / 0.5 h / 80 °C

9: 78 percent / acetonitrile / 1 h / Heating

With hydrogenchloride; cadmium(II) carbonate; hydrogen; sodium acetate; sodium hydrogencarbonate; acetic acid; mercury dichloride; palladium on activated charcoal; In pyridine; ethanol; chloroform; water; acetone; acetonitrile;
DOI:10.1016/S0040-4020(01)89805-7