1-benzyl-5-methoxy-3-<1-hydroxy-6-(trimethylsilyl)-4-hexynyl>-2-pyrrolidinone

Base Information

Chemical Name:1-benzyl-5-methoxy-3-<1-hydroxy-6-(trimethylsilyl)-4-hexynyl>-2-pyrrolidinone
CAS No.:117416-15-6
Molecular Formula:C₂₁H₃₁NO₃Si
Molecular Weight:373.568
Hs Code.:

Synonyms:1-benzyl-5-methoxy-3-<1-hydroxy-6-(trimethylsilyl)-4-hexynyl>-2-pyrrolidinone

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-benzyl-5-methoxy-3-<1-hydroxy-6-(trimethylsilyl)-4-hexynyl>-2-pyrrolidinone

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Technology Process of 1-benzyl-5-methoxy-3-<1-hydroxy-6-(trimethylsilyl)-4-hexynyl>-2-pyrrolidinone

There total 3 articles about 1-benzyl-5-methoxy-3-<1-hydroxy-6-(trimethylsilyl)-4-hexynyl>-2-pyrrolidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 41194-03-0,136410-26-9
1-benzyl-5-methoxypyrrolidin-2-one

: 117416-13-4
6-(trimethylsilyl)hex-4-ynal

: 117416-15-6
1-benzyl-5-methoxy-3-<1-hydroxy-6-(trimethylsilyl)-4-hexynyl>-2-pyrrolidinone

Guidance literature:: With lithium diisopropyl amide; In tetrahydrofuran; at -78 - 20 ℃; for 2h;
DOI:10.1016/S0040-4020(01)86638-2

Reference yield:

: 2142-06-5
1-(phenylmethyl)-2,5-pyrrolidinedione

: 117416-15-6
1-benzyl-5-methoxy-3-<1-hydroxy-6-(trimethylsilyl)-4-hexynyl>-2-pyrrolidinone

Guidance literature:: Multi-step reaction with 2 steps

1: 56 percent / sodium borohydride, 2 M HCl / 4 h / 0 - 5 °C

2: 50 percent / LDA / tetrahydrofuran / 2 h / -78 - 20 °C

With hydrogenchloride; sodium tetrahydroborate; lithium diisopropyl amide; In tetrahydrofuran;
DOI:10.1016/S0040-4020(01)86638-2

Reference yield:

: 76711-41-6
1-(Trimethylsilyl)-2-hexyn-6-ol

: 117416-15-6
1-benzyl-5-methoxy-3-<1-hydroxy-6-(trimethylsilyl)-4-hexynyl>-2-pyrrolidinone

Guidance literature:: Multi-step reaction with 2 steps

1: 81 percent / CrO₃, pyridine

2: 50 percent / LDA / tetrahydrofuran / 2 h / -78 - 20 °C

With pyridine; chromium(VI) oxide; lithium diisopropyl amide; In tetrahydrofuran;
DOI:10.1016/S0040-4020(01)86638-2