(4-((3aS,4S,6R,6aR)-6-((tert-butyldiphenylsilyloxy)methyl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)-2-cyanothiophen-3-yl)-N,N-dimethylformimidamide

Base Information

Chemical Name:(4-((3aS,4S,6R,6aR)-6-((tert-butyldiphenylsilyloxy)methyl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)-2-cyanothiophen-3-yl)-N,N-dimethylformimidamide
CAS No.:1370007-72-9
Molecular Formula:C₃₂H₃₉N₃O₄SSi
Molecular Weight:589.831
Hs Code.:

(4-((3aS,4S,6R,6aR)-6-((tert-butyldiphenylsilyloxy)methyl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)-2-cyanothiophen-3-yl)-N,N-dimethylformimidamide

Synonyms:(4-((3aS,4S,6R,6aR)-6-((tert-butyldiphenylsilyloxy)methyl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)-2-cyanothiophen-3-yl)-N,N-dimethylformimidamide

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Chemical Property of (4-((3aS,4S,6R,6aR)-6-((tert-butyldiphenylsilyloxy)methyl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)-2-cyanothiophen-3-yl)-N,N-dimethylformimidamide

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Technology Process of (4-((3aS,4S,6R,6aR)-6-((tert-butyldiphenylsilyloxy)methyl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)-2-cyanothiophen-3-yl)-N,N-dimethylformimidamide

There total 6 articles about (4-((3aS,4S,6R,6aR)-6-((tert-butyldiphenylsilyloxy)methyl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)-2-cyanothiophen-3-yl)-N,N-dimethylformimidamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1370007-66-1
4-[(3aS,4S,6R,6aR)-6-[(tert-butyl(diphenyl)silyl)oxymethyl]-2,2-dimethyl-3a,4,6,6a-tetrahydrofuro[3,4-d][1,3]dioxol-4-yl]-3-amino-thiophene-2-carbonitrile

: 4637-24-5
N,N-dimethyl-formamide dimethyl acetal

: 1370007-72-9
(4-((3aS,4S,6R,6aR)-6-((tert-butyldiphenylsilyloxy)methyl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)-2-cyanothiophen-3-yl)-N,N-dimethylformimidamide

Guidance literature:: In toluene; at 110 ℃; for 4h;

Reference yield:

: 1370007-65-0
2-((3aS,6R,6aR)-6-(((tert-butyldiphenylsilyl)oxy)methyl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)-3-(dimethylamino)acrylonitrile

: 1370007-72-9
(4-((3aS,4S,6R,6aR)-6-((tert-butyldiphenylsilyloxy)methyl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)-2-cyanothiophen-3-yl)-N,N-dimethylformimidamide

Guidance literature:: Multi-step reaction with 4 steps

1: trifluoroacetic acid / chloroform; water / 20 °C

2: triethylamine / dichloromethane / 1.17 h / 0 °C

3: sodium carbonate / ethanol / 6 h / Inert atmosphere; Reflux

4: toluene / 4 h / 110 °C

With sodium carbonate; triethylamine; trifluoroacetic acid; In ethanol; dichloromethane; chloroform; water; toluene;

Reference yield:

: 1370007-62-7
2-((3aS,6R,6aR)-6-(((tert-butyldiphenylsilyl)oxy)methyl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)acetonitrile

: 1370007-72-9
(4-((3aS,4S,6R,6aR)-6-((tert-butyldiphenylsilyloxy)methyl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)-2-cyanothiophen-3-yl)-N,N-dimethylformimidamide

Guidance literature:: Multi-step reaction with 5 steps

1: N,N-dimethyl-formamide / 20 °C

2: trifluoroacetic acid / chloroform; water / 20 °C

3: triethylamine / dichloromethane / 1.17 h / 0 °C

4: sodium carbonate / ethanol / 6 h / Inert atmosphere; Reflux

5: toluene / 4 h / 110 °C

With sodium carbonate; triethylamine; trifluoroacetic acid; In ethanol; dichloromethane; chloroform; water; N,N-dimethyl-formamide; toluene;