4-[(3aS,4S,6R,6aR)-6-[(tert-butyl(diphenyl)silyl)oxymethyl]-2,2-dimethyl-3a,4,6,6a-tetrahydrofuro[3,4-d][1,3]dioxol-4-yl]-3-amino-thiophene-2-carbonitrile

Base Information

Chemical Name:4-[(3aS,4S,6R,6aR)-6-[(tert-butyl(diphenyl)silyl)oxymethyl]-2,2-dimethyl-3a,4,6,6a-tetrahydrofuro[3,4-d][1,3]dioxol-4-yl]-3-amino-thiophene-2-carbonitrile
CAS No.:1370007-66-1
Molecular Formula:C₂₉H₃₄N₂O₄SSi
Molecular Weight:534.751
Hs Code.:

4-[(3aS,4S,6R,6aR)-6-[(tert-butyl(diphenyl)silyl)oxymethyl]-2,2-dimethyl-3a,4,6,6a-tetrahydrofuro[3,4-d][1,3]dioxol-4-yl]-3-amino-thiophene-2-carbonitrile

Synonyms:4-[(3aS,4S,6R,6aR)-6-[(tert-butyl(diphenyl)silyl)oxymethyl]-2,2-dimethyl-3a,4,6,6a-tetrahydrofuro[3,4-d][1,3]dioxol-4-yl]-3-amino-thiophene-2-carbonitrile

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Chemical Property of 4-[(3aS,4S,6R,6aR)-6-[(tert-butyl(diphenyl)silyl)oxymethyl]-2,2-dimethyl-3a,4,6,6a-tetrahydrofuro[3,4-d][1,3]dioxol-4-yl]-3-amino-thiophene-2-carbonitrile

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Technology Process of 4-[(3aS,4S,6R,6aR)-6-[(tert-butyl(diphenyl)silyl)oxymethyl]-2,2-dimethyl-3a,4,6,6a-tetrahydrofuro[3,4-d][1,3]dioxol-4-yl]-3-amino-thiophene-2-carbonitrile

There total 5 articles about 4-[(3aS,4S,6R,6aR)-6-[(tert-butyl(diphenyl)silyl)oxymethyl]-2,2-dimethyl-3a,4,6,6a-tetrahydrofuro[3,4-d][1,3]dioxol-4-yl]-3-amino-thiophene-2-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 59463-56-8
thioacetic acid S-cyanomethyl ester

: 1370007-67-2
2-((3aS,6R,6aR)-6-(((tert-butyldiphenylsilyl)oxy)methyl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)-2-cyanovinyl methanesulfonate

: 1370007-66-1
4-[(3aS,4S,6R,6aR)-6-[(tert-butyl(diphenyl)silyl)oxymethyl]-2,2-dimethyl-3a,4,6,6a-tetrahydrofuro[3,4-d][1,3]dioxol-4-yl]-3-amino-thiophene-2-carbonitrile

Guidance literature:: With sodium carbonate; In ethanol; for 6h; Inert atmosphere; Reflux;

Reference yield:

: 96690-02-7
5-O-(tert-butyldiphenylsilyl)-2,3-O-isopropylidene-D-ribofuranose

: 1370007-66-1
4-[(3aS,4S,6R,6aR)-6-[(tert-butyl(diphenyl)silyl)oxymethyl]-2,2-dimethyl-3a,4,6,6a-tetrahydrofuro[3,4-d][1,3]dioxol-4-yl]-3-amino-thiophene-2-carbonitrile

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydride / 1,2-dimethoxyethane; mineral oil / 0.17 h / 0 °C

1.2: 2 h / 20 °C

2.1: N,N-dimethyl-formamide / 20 °C

3.1: trifluoroacetic acid / chloroform; water / 20 °C

4.1: triethylamine / dichloromethane / 1.17 h / 0 °C

5.1: sodium carbonate / ethanol / 6 h / Inert atmosphere; Reflux

With sodium hydride; sodium carbonate; triethylamine; trifluoroacetic acid; In 1,2-dimethoxyethane; ethanol; dichloromethane; chloroform; water; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 1370007-62-7
2-((3aS,6R,6aR)-6-(((tert-butyldiphenylsilyl)oxy)methyl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)acetonitrile

: 1370007-66-1
4-[(3aS,4S,6R,6aR)-6-[(tert-butyl(diphenyl)silyl)oxymethyl]-2,2-dimethyl-3a,4,6,6a-tetrahydrofuro[3,4-d][1,3]dioxol-4-yl]-3-amino-thiophene-2-carbonitrile

Guidance literature:: Multi-step reaction with 4 steps

1: N,N-dimethyl-formamide / 20 °C

2: trifluoroacetic acid / chloroform; water / 20 °C

3: triethylamine / dichloromethane / 1.17 h / 0 °C

4: sodium carbonate / ethanol / 6 h / Inert atmosphere; Reflux

With sodium carbonate; triethylamine; trifluoroacetic acid; In ethanol; dichloromethane; chloroform; water; N,N-dimethyl-formamide;