tert-butyl 4-(4-{1-[(tert-butoxy)carbonyl]-5-(4-methoxyphenyl)-1H-pyrrol-3-yl}buta-1,3-diyn-1-yl)-2-(4-methoxyphenyl)-1H-pyrrole-1-carboxylate

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Chemical Name:tert-butyl 4-(4-{1-[(tert-butoxy)carbonyl]-5-(4-methoxyphenyl)-1H-pyrrol-3-yl}buta-1,3-diyn-1-yl)-2-(4-methoxyphenyl)-1H-pyrrole-1-carboxylate
CAS No.:1266358-08-0
Molecular Formula:C₃₆H₃₆N₂O₆
Molecular Weight:592.692
Hs Code.:

Synonyms:tert-butyl 4-(4-{1-[(tert-butoxy)carbonyl]-5-(4-methoxyphenyl)-1H-pyrrol-3-yl}buta-1,3-diyn-1-yl)-2-(4-methoxyphenyl)-1H-pyrrole-1-carboxylate

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Chemical Property of tert-butyl 4-(4-{1-[(tert-butoxy)carbonyl]-5-(4-methoxyphenyl)-1H-pyrrol-3-yl}buta-1,3-diyn-1-yl)-2-(4-methoxyphenyl)-1H-pyrrole-1-carboxylate

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Technology Process of tert-butyl 4-(4-{1-[(tert-butoxy)carbonyl]-5-(4-methoxyphenyl)-1H-pyrrol-3-yl}buta-1,3-diyn-1-yl)-2-(4-methoxyphenyl)-1H-pyrrole-1-carboxylate

There total 2 articles about tert-butyl 4-(4-{1-[(tert-butoxy)carbonyl]-5-(4-methoxyphenyl)-1H-pyrrol-3-yl}buta-1,3-diyn-1-yl)-2-(4-methoxyphenyl)-1H-pyrrole-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 1159581-63-1
tert-butyl 4-iodo-2-(4-methoxy-phenyl)-1H-pyrrole-1-carboxylate

: 1066-54-2
trimethylsilylacetylene

: 1266358-08-0
tert-butyl 4-(4-{1-[(tert-butoxy)carbonyl]-5-(4-methoxyphenyl)-1H-pyrrol-3-yl}buta-1,3-diyn-1-yl)-2-(4-methoxyphenyl)-1H-pyrrole-1-carboxylate

Guidance literature:: tert-butyl 4-iodo-2-(4-methoxy-phenyl)-1H-pyrrole-1-carboxylate; trimethylsilylacetylene; With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; In tetrahydrofuran; at 20 ℃; for 2h;

With potassium fluoride; oxygen; In tetrahydrofuran; methanol; at 50 ℃; for 25h;
DOI:10.1002/ejoc.201001472

Reference yield:

: 92136-39-5
N-tert-Butoxycarbonyl-1-amino-3-propyne

: 100-07-2
4-methoxy-benzoyl chloride

: 1266358-08-0
tert-butyl 4-(4-{1-[(tert-butoxy)carbonyl]-5-(4-methoxyphenyl)-1H-pyrrol-3-yl}buta-1,3-diyn-1-yl)-2-(4-methoxyphenyl)-1H-pyrrole-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / tetrahydrofuran / 1 h / 20 °C

1.2: 1 h / 20 °C / Inert atmosphere

2.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / tetrahydrofuran / 2 h / 20 °C

2.2: 25 h / 50 °C

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; In tetrahydrofuran; 2.1: Sonogashira coupling / 2.2: Glaser coupling;
DOI:10.1002/ejoc.201001472