1-(4-fluoro-phenyl)-4-(4-methylsulfamoyl-benzylcarbamoyl)-1H-indazole-6-carboxylic acid

Base Information

Chemical Name:1-(4-fluoro-phenyl)-4-(4-methylsulfamoyl-benzylcarbamoyl)-1H-indazole-6-carboxylic acid
CAS No.:1194019-43-6
Molecular Formula:C₂₃H₁₉FN₄O₅S
Molecular Weight:482.492
Hs Code.:

Synonyms:1-(4-fluoro-phenyl)-4-(4-methylsulfamoyl-benzylcarbamoyl)-1H-indazole-6-carboxylic acid

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Chemical Property of 1-(4-fluoro-phenyl)-4-(4-methylsulfamoyl-benzylcarbamoyl)-1H-indazole-6-carboxylic acid

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Technology Process of 1-(4-fluoro-phenyl)-4-(4-methylsulfamoyl-benzylcarbamoyl)-1H-indazole-6-carboxylic acid

There total 10 articles about 1-(4-fluoro-phenyl)-4-(4-methylsulfamoyl-benzylcarbamoyl)-1H-indazole-6-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1194019-41-4
1-(4-fluoro-phenyl)-4-(4-methylsulfamoyl-benzylcarbamoyl)-1H-indazole-6-carboxylic acid ethyl ester

: 1194019-43-6
1-(4-fluoro-phenyl)-4-(4-methylsulfamoyl-benzylcarbamoyl)-1H-indazole-6-carboxylic acid

Guidance literature:: 1-(4-fluoro-phenyl)-4-(4-methylsulfamoyl-benzylcarbamoyl)-1H-indazole-6-carboxylic acid ethyl ester; With water; potassium hydroxide; In ethanol; for 1h; Reflux;

With hydrogenchloride; In ethanol; water; at 20 ℃; pH=3 - 4;

Reference yield:

: 864528-61-0
4-(azidomethyl)-N-methylbenzenesulfonamide

: 1194019-43-6
1-(4-fluoro-phenyl)-4-(4-methylsulfamoyl-benzylcarbamoyl)-1H-indazole-6-carboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: cyclohexa-1,4-diene / 10 wt% Pd(OH)2 on carbon / methanol / 2 h / 65 °C

2.1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; triethylamine / N,N-dimethyl-formamide / 0.25 h / 20 °C

2.2: 5 h

3.1: triethylamine / bis(benzonitrile)palladium(II) dichloride; 1,1'-bis(diphenylphosphino)ferrocene / 4 h / 140 °C / 11251.1 Torr / sealed tube

4.1: water; potassium hydroxide / ethanol / 1 h / Reflux

4.2: 20 °C / pH 3 - 4

With cyclohexa-1,4-diene; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; water; triethylamine; potassium hydroxide; bis(benzonitrile)palladium(II) dichloride; 1,1'-bis(diphenylphosphino)ferrocene; 10 wt% Pd(OH)2 on carbon; In methanol; ethanol; N,N-dimethyl-formamide;

Reference yield:

: 1194020-02-4
6-bromo-1-(4-fluoro-phenyl)-1H-indazole-4-carboxylic acid

: 1194019-43-6
1-(4-fluoro-phenyl)-4-(4-methylsulfamoyl-benzylcarbamoyl)-1H-indazole-6-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; triethylamine / N,N-dimethyl-formamide / 0.25 h / 20 °C

1.2: 5 h

2.1: triethylamine / bis(benzonitrile)palladium(II) dichloride; 1,1'-bis(diphenylphosphino)ferrocene / 4 h / 140 °C / 11251.1 Torr / sealed tube

3.1: water; potassium hydroxide / ethanol / 1 h / Reflux

3.2: 20 °C / pH 3 - 4

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; water; triethylamine; potassium hydroxide; bis(benzonitrile)palladium(II) dichloride; 1,1'-bis(diphenylphosphino)ferrocene; In ethanol; N,N-dimethyl-formamide;