1-(4-fluoro-phenyl)-1H-indazole-4,6-dicarboxylic acid 6-methylamide 4-(4-methylsulfamoyl-benzylamide)

Base Information

Chemical Name:1-(4-fluoro-phenyl)-1H-indazole-4,6-dicarboxylic acid 6-methylamide 4-(4-methylsulfamoyl-benzylamide)
CAS No.:1194019-45-8
Molecular Formula:C₂₄H₂₂FN₅O₄S
Molecular Weight:495.534
Hs Code.:

Synonyms:1-(4-fluoro-phenyl)-1H-indazole-4,6-dicarboxylic acid 6-methylamide 4-(4-methylsulfamoyl-benzylamide)

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Chemical Property of 1-(4-fluoro-phenyl)-1H-indazole-4,6-dicarboxylic acid 6-methylamide 4-(4-methylsulfamoyl-benzylamide)

Chemical Property:

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Technology Process of 1-(4-fluoro-phenyl)-1H-indazole-4,6-dicarboxylic acid 6-methylamide 4-(4-methylsulfamoyl-benzylamide)

There total 11 articles about 1-(4-fluoro-phenyl)-1H-indazole-4,6-dicarboxylic acid 6-methylamide 4-(4-methylsulfamoyl-benzylamide) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1194019-43-6
1-(4-fluoro-phenyl)-4-(4-methylsulfamoyl-benzylcarbamoyl)-1H-indazole-6-carboxylic acid

: 593-51-1
methylamine hydrochloride

: 1194019-45-8
1-(4-fluoro-phenyl)-1H-indazole-4,6-dicarboxylic acid 6-methylamide 4-(4-methylsulfamoyl-benzylamide)

Guidance literature:: 1-(4-fluoro-phenyl)-4-(4-methylsulfamoyl-benzylcarbamoyl)-1H-indazole-6-carboxylic acid; With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 0.25h;

methylamine hydrochloride; In N,N-dimethyl-formamide; for 5h;

Reference yield:

: 864528-61-0
4-(azidomethyl)-N-methylbenzenesulfonamide

: 1194019-45-8
1-(4-fluoro-phenyl)-1H-indazole-4,6-dicarboxylic acid 6-methylamide 4-(4-methylsulfamoyl-benzylamide)

Guidance literature:: Multi-step reaction with 5 steps

1.1: cyclohexa-1,4-diene / 10 wt% Pd(OH)2 on carbon / methanol / 2 h / 65 °C

2.1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; triethylamine / N,N-dimethyl-formamide / 0.25 h / 20 °C

2.2: 5 h

3.1: triethylamine / bis(benzonitrile)palladium(II) dichloride; 1,1'-bis(diphenylphosphino)ferrocene / 4 h / 140 °C / 11251.1 Torr / sealed tube

4.1: water; potassium hydroxide / ethanol / 1 h / Reflux

4.2: 20 °C / pH 3 - 4

5.1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; triethylamine / N,N-dimethyl-formamide / 0.25 h / 20 °C

5.2: 5 h

With cyclohexa-1,4-diene; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; water; triethylamine; potassium hydroxide; bis(benzonitrile)palladium(II) dichloride; 1,1'-bis(diphenylphosphino)ferrocene; 10 wt% Pd(OH)2 on carbon; In methanol; ethanol; N,N-dimethyl-formamide;

Reference yield:

: 1194020-02-4
6-bromo-1-(4-fluoro-phenyl)-1H-indazole-4-carboxylic acid

: 1194019-45-8
1-(4-fluoro-phenyl)-1H-indazole-4,6-dicarboxylic acid 6-methylamide 4-(4-methylsulfamoyl-benzylamide)

Guidance literature:: Multi-step reaction with 4 steps

1.1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; triethylamine / N,N-dimethyl-formamide / 0.25 h / 20 °C

1.2: 5 h

2.1: triethylamine / bis(benzonitrile)palladium(II) dichloride; 1,1'-bis(diphenylphosphino)ferrocene / 4 h / 140 °C / 11251.1 Torr / sealed tube

3.1: water; potassium hydroxide / ethanol / 1 h / Reflux

3.2: 20 °C / pH 3 - 4

4.1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; triethylamine / N,N-dimethyl-formamide / 0.25 h / 20 °C

4.2: 5 h

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; water; triethylamine; potassium hydroxide; bis(benzonitrile)palladium(II) dichloride; 1,1'-bis(diphenylphosphino)ferrocene; In ethanol; N,N-dimethyl-formamide;