2-{2-{-2{-2(benzyloxy)propanoyloxy}propanoyloxy}propanoyloxy}propanoicacid-tert.butylester

Base Information

• Chemical Name: 2-{2-{-2{-2(benzyloxy)propanoyloxy}propanoyloxy}propanoyloxy}propanoicacid-tert.butylester
• CAS No.: 1053719-22-4
• Molecular Formula: C₂₃H₃₂O₉
• Molecular Weight: 452.502
• Mol file: 1053719-22-4.mol

Synonyms:2-{2-{-2{-2(benzyloxy)propanoyloxy}propanoyloxy}propanoyloxy}propanoicacid-tert.butylester

Chemical Property of 2-{2-{-2{-2(benzyloxy)propanoyloxy}propanoyloxy}propanoyloxy}propanoicacid-tert.butylester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-{2-{-2{-2(benzyloxy)propanoyloxy}propanoyloxy}propanoyloxy}propanoicacid-tert.butylester

There total 5 articles about 2-{2-{-2{-2(benzyloxy)propanoyloxy}propanoyloxy}propanoyloxy}propanoicacid-tert.butylester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 10.0%

2-{2-(benzyloxy)-propanoyloxy}propanoic acid (1053718-97-0) + 2-{2-hydroxypropanoyloxy}propanoic acid tert-butyl ester → 2-{2-{-2{-2(benzyloxy)propanoyloxy}propanoyloxy}propanoyloxy}propanoicacid-tert.butylester (1053719-22-4)

Guidance literature:

2-{2-(benzyloxy)-propanoyloxy}propanoic acid; With 2-chloro-1-methyl-pyridinium iodide; triethylamine; In dichloromethane; for 1h; Inert atmosphere; Reflux;

2-{2-hydroxypropanoyloxy}propanoic acid tert-butyl ester; In dichloromethane; for 20h; Inert atmosphere; Reflux;

DOI:10.1691/ph.2013.2686

Reference yield:

(S)-2-(benzyloxy)propanoic acid (33106-32-0) → 2-{2-{-2{-2(benzyloxy)propanoyloxy}propanoyloxy}propanoyloxy}propanoicacid-tert.butylester (1053719-22-4)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 2-chloro-1-methyl-pyridinium iodide; triethylamine / dichloromethane / 48 h / Reflux

2.1: trifluoroacetic acid / dichloromethane / 4 h / Reflux

3.1: 2-chloro-1-methyl-pyridinium iodide; triethylamine / dichloromethane / 1 h / Inert atmosphere; Reflux

3.2: 20 h / Inert atmosphere; Reflux

With 2-chloro-1-methyl-pyridinium iodide; triethylamine; trifluoroacetic acid; In dichloromethane;

DOI:10.1691/ph.2013.2686

Reference yield:

(+)-tert-butyl D-lactate (13650-70-9) → 2-{2-{-2{-2(benzyloxy)propanoyloxy}propanoyloxy}propanoyloxy}propanoicacid-tert.butylester (1053719-22-4)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 2-chloro-1-methyl-pyridinium iodide; triethylamine / dichloromethane / 48 h / Reflux

2.1: palladium 10% on activated carbon; hydrogen / diethyl ether

3.1: 2-chloro-1-methyl-pyridinium iodide; triethylamine / dichloromethane / 1 h / Inert atmosphere; Reflux

3.2: 20 h / Inert atmosphere; Reflux

With palladium 10% on activated carbon; 2-chloro-1-methyl-pyridinium iodide; hydrogen; triethylamine; In diethyl ether; dichloromethane;

DOI:10.1691/ph.2013.2686

upstream raw materials:

(S)-2-(benzyloxy)propanoic acid

(+)-tert-butyl D-lactate

2-{2-(benzyloxy)-propanoyloxy}propanoic acid