13650-70-9

Basic information

• Product Name: tert-Butyl L-lactate
• Synonyms: tert-Butyl L-lactate;tert-Butyl (S)-(-)-lactate;(S)-tert-butyl 2-hydroxypropanoate
• CAS NO: 13650-70-9
• Molecular Formula: C₇H₁₄O₃
• Molecular Weight: 146.09
• Product Categories: API intermediates
• Mol File: 13650-70-9.mol
• Article Data: 15

Chemical Properties

• Melting Point: 42 °C
• Boiling Point: 161.821 °C at 760 mmHg
• Flash Point: 49.141 °C
• Appearance: /
• Density: 1.005 g/cm³
• Vapor Pressure: 0.77mmHg at 25°C
• Refractive Index: 1.431
• PKA: 13.07±0.20(Predicted)
• CAS DataBase Reference: tert-Butyl L-lactate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-Butyl L-lactate(13650-70-9)
• EPA Substance Registry System: tert-Butyl L-lactate(13650-70-9)

Safety Data

• Hazardous Substances Data: 13650-70-9(Hazardous Substances Data)

Usage

General Description

Tert-Butyl L-lactate is a chemical compound commonly used as a flavoring agent and fragrance ingredient in the food and cosmetic industries. It is a derivative of lactic acid, a naturally occurring organic acid, and is typically synthesized through the esterification of lactic acid with tert-butanol. Tert-Butyl L-lactate is known for its fruity and sweet odor and is often employed to enhance the aromatic profile of various products. Additionally, it is utilized as a solvent and as a starting material for the synthesis of other chemicals. Due to its low toxicity and pleasant scent, tert-Butyl L-lactate is widely utilized in a range of consumer goods and industrial applications.

InChI:InChI=1/C7H14O3/c1-5(8)6(9)10-7(2,3)4/h5,8H,1-4H3/t5-/m0/s1

Upstream product

• 76849-54-2 t-butyl pyruvate 
• 540-88-5 acetic acid tert-butyl ester 
• 79-33-4 L-Lactic acid 
• 115-11-7 isobutene 
• 75-65-0 tert-butyl alcohol 
• 120444-05-5 (?)-(2S)-acetoxypropionic acid tert-butyl ester 
• 535-17-1 (S)-2-acetoxypropionic acid 
• 71432-55-8 2-tert-butyl-1,3-diisopropylisourea 

Downstream Products

• 380886-41-9 D-tert-butyl 2-p-chlorophenylcarbonyl-aminoxy-propanoate 
• 1091604-01-1 C₂₆H₂₉N₃O₇ 
• 1053719-22-4 2-{2-{-2{-2(benzyloxy)propanoyloxy}propanoyloxy}propanoyloxy}propanoicacid-tert.butylester 
• 1053719-26-8 2-{2-{-2{-2(benzyloxy)propanoyloxy}propanoyloxy}propanoyloxy}propanoicacid-tert.butylester 
• 1053719-25-7 2-{2-{-2{-2(benzyloxy)propanoyloxy}propanoyloxy}propanoyloxy}propanoicacid-tert.butylester 
• 1053719-27-9 2-{2-{-2{-2(benzyloxy)propanoyloxy}propanoyloxy}propanoyloxy}propanoicacid-tert.butylester 
• 1053719-20-2 2-{2-{-2{-2(benzyloxy)propanoyloxy}propanoyloxy}propanoyloxy}propanoicacid-tert.butylester 
• 1053719-17-7 2-{2-{-2{-2(benzyloxy)propanoyloxy}propanoyloxy}propanoyloxy}propanoicacid-tert.butylester 
• 1029715-06-7 tert-butyl 2-[4-(2-aminopyrimidin-5-yl)-2-fluorophenoxy]propionate 

Relevant articles and documents

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Preparation method of (R)-(+)-2-p-hydroxyl phenoxyl propionic acid

The invention relates to a preparation method of (R)-(+)-2-p-hydroxyl phenoxyl propionic acid. The method comprises the following steps of taking (S)-(-)-lactic acid as a raw material, and performingthree-step reaction, i.e., esterification, nucleophilic substitution and hydrolysis to obtain a target compound. A synthetic process for the (R)-(+)-2-p-hydroxyl phenoxyl propionic acid is further optimized, and the optimum reaction condition and reagent are screened. According to the preparation method designed in the invention, the reaction steps are shortened, and the yield and optical purity of the (R)-(+)-2-p-hydroxyl phenoxyl propionic acid are improved.

α-Aminoxy Oligopeptides: Synthesis, Secondary Structure, and Cytotoxicity of a New Class of Anticancer Foldamers

α-Aminoxy peptides are peptidomimetic foldamers with high proteolytic and conformational stability. To gain an improved synthetic access to α-aminoxy oligopeptides we used a straightforward combination of solution- and solid-phase-supported methods and obtained oligomers that showed a remarkable anticancer activity against a panel of cancer cell lines. We solved the first X-ray crystal structure of an α-aminoxy peptide with multiple turns around the helical axis. The crystal structure revealed a right-handed 28-helical conformation with precisely two residues per turn and a helical pitch of 5.8 ?. By 2D ROESY experiments, molecular dynamics simulations, and CD spectroscopy we were able to identify the 28-helix as the predominant conformation in organic solvents. In aqueous solution, the α-aminoxy peptides exist in the 28-helical conformation at acidic pH, but exhibit remarkable changes in the secondary structure with increasing pH. The most cytotoxic α-aminoxy peptides have an increased propensity to take up a 28-helical conformation in the presence of a model membrane. This indicates a correlation between the 28-helical conformation and the membranolytic activity observed in mode of action studies, thereby providing novel insights in the folding properties and the biological activity of α-aminoxy peptides.

Total synthesis of carolacton, a highly potent biofilm inhibitor

Metals are the key players in the synthesis of caralacton, a strong inhibitor of bacterial biofilms. The total synthesis is based on several metal-mediated key transformations such as the Ley and the Duthaler-Hafner aldol reactions, the Marshall reaction and Breit's substitution, as well as the Nozaki-Hiyama-Kishi and Negishi-Fu C-C coupling reactions. Copyright