(2S,4R)-5-(3-bromo-2,5-diisopropoxy-6-methoxyphenyl)-2-methoxy-4-methylpentanal

Base Information

• Chemical Name: (2S,4R)-5-(3-bromo-2,5-diisopropoxy-6-methoxyphenyl)-2-methoxy-4-methylpentanal
• CAS No.: 1033591-45-5
• Molecular Formula: C₂₀H₃₁BrO₅
• Molecular Weight: 431.367
• Mol file: 1033591-45-5.mol

Synonyms:(2S,4R)-5-(3-bromo-2,5-diisopropoxy-6-methoxyphenyl)-2-methoxy-4-methylpentanal

Chemical Property of (2S,4R)-5-(3-bromo-2,5-diisopropoxy-6-methoxyphenyl)-2-methoxy-4-methylpentanal

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2S,4R)-5-(3-bromo-2,5-diisopropoxy-6-methoxyphenyl)-2-methoxy-4-methylpentanal

There total 1 articles about (2S,4R)-5-(3-bromo-2,5-diisopropoxy-6-methoxyphenyl)-2-methoxy-4-methylpentanal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

(2R,3S,5R)-6-(3-bromo-2,5-diisopropoxy-6-methoxyphenyl)-3-methoxy-5-methylhexane-1,2-diol (1033591-55-7) → (2S,4R)-5-(3-bromo-2,5-diisopropoxy-6-methoxyphenyl)-2-methoxy-4-methylpentanal (1033591-45-5)

Guidance literature:

With sodium periodate; water; sodium hydrogencarbonate; In acetone; at 20 ℃; for 0.833333h; Inert atmosphere;

DOI:10.1021/ol800749w

Reference yield: 70.0%

methyl (2R,3R,E)-3-(dimethyl(phenyl)silyl)-2-(methoxymethoxy)-3-methylhex-4-enoate (1033591-44-4) + (2S,4R)-5-(3-bromo-2,5-diisopropoxy-6-methoxyphenyl)-2-methoxy-4-methylpentanal (1033591-45-5) + benzyloxy-trimethylsilane (14642-79-6) → methyl (2S,7S,9R)-6-(benzyloxy)-10-(3-bromo-2,5-diisopropoxy-6-methoxyphenyl)-7-methoxy-2-(methoxymethoxy)-3,5,9-trimethyldec-3-enoate + methyl (2S,5S,6R,7S,9R,E)-6-(benzyloxy)-10-(3-bromo-2,5-diisopropoxy-6-methoxyphenyl)-7-methoxy-2-(methoxymethoxy)-3,5,9-trimethyldec-3-enoate (1033591-56-8)

Guidance literature:

With boron trifluoride diethyl etherate; In dichloromethane; at -78 - -25 ℃; for 73h; optical yield given as %de; stereoselective reaction; Inert atmosphere;

DOI:10.1021/ol800749w

upstream raw materials:

(2R,3S,5R)-6-(3-bromo-2,5-diisopropoxy-6-methoxyphenyl)-3-methoxy-5-methylhexane-1,2-diol

Downstream raw materials:

methyl (2S,5S,6R,7S,9R,E)-6-(benzyloxy)-10-(3-bromo-2,5-diisopropoxy-6-methoxyphenyl)-7-methoxy-2-(methoxymethoxy)-3,5,9-trimethyldec-3-enoate