O-{{1-[(dimethylamino)sulfonyl]-2-[2-(4-pyridin-2-ylphenyl)ethyl]-1H-imidazol-4-yl}[1-(trifluoromethyl)cyclobutyl]methyl}-1H-imidazole-1-carbothioate

Base Information

• Chemical Name: O-{{1-[(dimethylamino)sulfonyl]-2-[2-(4-pyridin-2-ylphenyl)ethyl]-1H-imidazol-4-yl}[1-(trifluoromethyl)cyclobutyl]methyl}-1H-imidazole-1-carbothioate
• CAS No.: 1021939-68-3
• Molecular Formula: C₂₈H₂₉F₃N₆O₃S₂
• Molecular Weight: 618.704

Synonyms:O-{{1-[(dimethylamino)sulfonyl]-2-[2-(4-pyridin-2-ylphenyl)ethyl]-1H-imidazol-4-yl}[1-(trifluoromethyl)cyclobutyl]methyl}-1H-imidazole-1-carbothioate

Chemical Property of O-{{1-[(dimethylamino)sulfonyl]-2-[2-(4-pyridin-2-ylphenyl)ethyl]-1H-imidazol-4-yl}[1-(trifluoromethyl)cyclobutyl]methyl}-1H-imidazole-1-carbothioate

Chemical Property:

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Technology Process of O-{{1-[(dimethylamino)sulfonyl]-2-[2-(4-pyridin-2-ylphenyl)ethyl]-1H-imidazol-4-yl}[1-(trifluoromethyl)cyclobutyl]methyl}-1H-imidazole-1-carbothioate

There total 1 articles about O-{{1-[(dimethylamino)sulfonyl]-2-[2-(4-pyridin-2-ylphenyl)ethyl]-1H-imidazol-4-yl}[1-(trifluoromethyl)cyclobutyl]methyl}-1H-imidazole-1-carbothioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-{hydroxy[1-(trifluoromethyl)cyclobutyl]methyl}-N,N-dimethyl-2-[2-(4-pyridin-2-ylphenyl)ethyl]-1H-imidazole-1-sulfonamide (1021939-67-2) + 1,1'-Thiocarbonyldiimidazole (6160-65-2) → O-{{1-[(dimethylamino)sulfonyl]-2-[2-(4-pyridin-2-ylphenyl)ethyl]-1H-imidazol-4-yl}[1-(trifluoromethyl)cyclobutyl]methyl}-1H-imidazole-1-carbothioate (1021939-68-3)

Guidance literature:

dmap; In dichloromethane; at 20 ℃; for 24h;

Reference yield:

O-{{1-[(dimethylamino)sulfonyl]-2-[2-(4-pyridin-2-ylphenyl)ethyl]-1H-imidazol-4-yl}[1-(trifluoromethyl)cyclobutyl]methyl}-1H-imidazole-1-carbothioate (1021939-68-3) → N,N-dimethyl-2-[2-(4-pyridin-2-ylphenyl)ethyl]-4-{[1-(trifluoromethyl)cyclobutyl]methyl}-1H-imidazole-1-sulfonamide (1021939-69-4)

Guidance literature:

With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; In toluene; at 110 ℃; for 0.2h; Heating / reflux;

upstream raw materials:

4-{hydroxy[1-(trifluoromethyl)cyclobutyl]methyl}-N,N-dimethyl-2-[2-(4-pyridin-2-ylphenyl)ethyl]-1H-imidazole-1-sulfonamide

1,1'-Thiocarbonyldiimidazole

Downstream raw materials:

N,N-dimethyl-2-[2-(4-pyridin-2-ylphenyl)ethyl]-4-{[1-(trifluoromethyl)cyclobutyl]methyl}-1H-imidazole-1-sulfonamide

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