(3R)-N-benzyloxycarbonyl-3-aminomethyl-1-nitro-4-benzyloxycarbonylhexane

Base Information

Chemical Name:(3R)-N-benzyloxycarbonyl-3-aminomethyl-1-nitro-4-benzyloxycarbonylhexane
CAS No.:1445444-38-1
Molecular Formula:C₂₁H₂₄N₂O₆
Molecular Weight:400.431
Hs Code.:

Synonyms:(3R)-N-benzyloxycarbonyl-3-aminomethyl-1-nitro-4-benzyloxycarbonylhexane

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Chemical Property of (3R)-N-benzyloxycarbonyl-3-aminomethyl-1-nitro-4-benzyloxycarbonylhexane

Chemical Property:

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Technology Process of (3R)-N-benzyloxycarbonyl-3-aminomethyl-1-nitro-4-benzyloxycarbonylhexane

There total 6 articles about (3R)-N-benzyloxycarbonyl-3-aminomethyl-1-nitro-4-benzyloxycarbonylhexane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₃H₂₆N₂O₈

: 1445444-38-1
(3R)-N-benzyloxycarbonyl-3-aminomethyl-1-nitro-4-benzyloxycarbonylhexane

Guidance literature:: With sodium tetrahydroborate; In ethanol; at 0 ℃; for 2h; Inert atmosphere;
DOI:10.1055/s-0032-1318344

Reference yield:

: 1445443-43-5
(S)-benzyl 3-(benzyloxycarbonylamino)-4-hydroxybutanoate

: 1445444-38-1
(3R)-N-benzyloxycarbonyl-3-aminomethyl-1-nitro-4-benzyloxycarbonylhexane

Guidance literature:: Multi-step reaction with 4 steps

1.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.42 h / -78 °C / Inert atmosphere

1.2: 0.25 h / -78 °C / Inert atmosphere

2.1: potassium fluoride / isopropyl alcohol / 8 h / 0 - 20 °C

3.1: dmap / diethyl ether / 2 h / 25 °C / Inert atmosphere

4.1: sodium tetrahydroborate / ethanol / 2 h / 0 °C / Inert atmosphere

With dmap; potassium fluoride; sodium tetrahydroborate; oxalyl dichloride; dimethyl sulfoxide; In diethyl ether; ethanol; dichloromethane; isopropyl alcohol; 1.1: |Swern Oxidation / 1.2: |Swern Oxidation / 2.1: |Henry Nitro Aldol Condensation;
DOI:10.1055/s-0032-1318344

Reference yield:

: 1445443-71-9
C₂₀H₂₁NO₅

: 1445444-38-1
(3R)-N-benzyloxycarbonyl-3-aminomethyl-1-nitro-4-benzyloxycarbonylhexane

Guidance literature:: Multi-step reaction with 3 steps

1: potassium fluoride / isopropyl alcohol / 8 h / 0 - 20 °C

2: dmap / diethyl ether / 2 h / 25 °C / Inert atmosphere

3: sodium tetrahydroborate / ethanol / 2 h / 0 °C / Inert atmosphere

With dmap; potassium fluoride; sodium tetrahydroborate; In diethyl ether; ethanol; isopropyl alcohol; 1: |Henry Nitro Aldol Condensation;
DOI:10.1055/s-0032-1318344