Technology Process of (3R)-N-benzyloxycarbonyl-3-aminomethyl-2-hydroxy-1-nitro-4-benzyloxycarbonylhexane
There total 4 articles about (3R)-N-benzyloxycarbonyl-3-aminomethyl-2-hydroxy-1-nitro-4-benzyloxycarbonylhexane which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
potassium fluoride;
In
isopropyl alcohol;
at 0 - 20 ℃;
for 8h;
DOI:10.1055/s-0032-1318344
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.42 h / -78 °C / Inert atmosphere
1.2: 0.25 h / -78 °C / Inert atmosphere
2.1: potassium fluoride / isopropyl alcohol / 8 h / 0 - 20 °C
With
potassium fluoride; oxalyl dichloride; dimethyl sulfoxide;
In
dichloromethane; isopropyl alcohol;
1.1: |Swern Oxidation / 1.2: |Swern Oxidation / 2.1: |Henry Nitro Aldol Condensation;
DOI:10.1055/s-0032-1318344
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: sodium tetrahydroborate / methanol; water / 0.25 h / -15 °C / Inert atmosphere
2.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.42 h / -78 °C / Inert atmosphere
2.2: 0.25 h / -78 °C / Inert atmosphere
3.1: potassium fluoride / isopropyl alcohol / 8 h / 0 - 20 °C
With
potassium fluoride; sodium tetrahydroborate; oxalyl dichloride; dimethyl sulfoxide;
In
methanol; dichloromethane; water; isopropyl alcohol;
2.1: |Swern Oxidation / 2.2: |Swern Oxidation / 3.1: |Henry Nitro Aldol Condensation;
DOI:10.1055/s-0032-1318344
