tert-butyl (3R,4R)-4-(4-fluorophenyl)-3-hydroxypiperidine-1-carboxylate

Base Information

Chemical Name:tert-butyl (3R,4R)-4-(4-fluorophenyl)-3-hydroxypiperidine-1-carboxylate
CAS No.:1448682-21-0
Molecular Formula:C₁₆H₂₂FNO₃
Molecular Weight:295.354
Hs Code.:

Synonyms:tert-butyl (3R,4R)-4-(4-fluorophenyl)-3-hydroxypiperidine-1-carboxylate

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Chemical Property of tert-butyl (3R,4R)-4-(4-fluorophenyl)-3-hydroxypiperidine-1-carboxylate

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Technology Process of tert-butyl (3R,4R)-4-(4-fluorophenyl)-3-hydroxypiperidine-1-carboxylate

There total 1 articles about tert-butyl (3R,4R)-4-(4-fluorophenyl)-3-hydroxypiperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.4%

: 138647-52-6
4-(4-fluorophenyl)-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester

: 1448682-21-0
tert-butyl (3R,4R)-4-(4-fluorophenyl)-3-hydroxypiperidine-1-carboxylate

Guidance literature:: 4-(4-fluorophenyl)-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester; With borane-THF; In tetrahydrofuran; at 40 ℃; Inert atmosphere;

With sodium hydroxide; In tetrahydrofuran; at 20 ℃; for 0.2h; Inert atmosphere;

With dihydrogen peroxide; In tetrahydrofuran; at 19 - 21 ℃; for 3h; Inert atmosphere;

Reference yield: 99.9%

: 1448682-21-0
tert-butyl (3R,4R)-4-(4-fluorophenyl)-3-hydroxypiperidine-1-carboxylate

: 74-88-4
methyl iodide

: 1448682-20-9
tert-butyl (3R,4R)-4-(4-fluorophenyl)-3-methoxypiperidine-1-carboxylate

Guidance literature:: tert-butyl (3R,4R)-4-(4-fluorophenyl)-3-hydroxypiperidine-1-carboxylate; With sodium hydride; In tetrahydrofuran; at 0 ℃; for 0.5h;

methyl iodide; In tetrahydrofuran; at 0 - 20 ℃; for 5h;