2,2,2-trifluoro-N-(4-(1-methyl-1H-indol-3-yl)-3-(3,4,5-trimethoxyphenyl)-1H-pyrazol-5-yl)acetamide

Base Information

Chemical Name:2,2,2-trifluoro-N-(4-(1-methyl-1H-indol-3-yl)-3-(3,4,5-trimethoxyphenyl)-1H-pyrazol-5-yl)acetamide
CAS No.:1313529-98-4
Molecular Formula:C₂₃H₂₁F₃N₄O₄
Molecular Weight:474.439
Hs Code.:

Synonyms:2,2,2-trifluoro-N-(4-(1-methyl-1H-indol-3-yl)-3-(3,4,5-trimethoxyphenyl)-1H-pyrazol-5-yl)acetamide

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Chemical Property of 2,2,2-trifluoro-N-(4-(1-methyl-1H-indol-3-yl)-3-(3,4,5-trimethoxyphenyl)-1H-pyrazol-5-yl)acetamide

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Technology Process of 2,2,2-trifluoro-N-(4-(1-methyl-1H-indol-3-yl)-3-(3,4,5-trimethoxyphenyl)-1H-pyrazol-5-yl)acetamide

There total 8 articles about 2,2,2-trifluoro-N-(4-(1-methyl-1H-indol-3-yl)-3-(3,4,5-trimethoxyphenyl)-1H-pyrazol-5-yl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 1313529-92-8
4-(1-methyl-1H-indol-3-yl)-3-(3,4,5-trimethoxyphenyl)-1H-pyrazol-5-amine

: 407-25-0
trifluoroacetic anhydride

: 1313529-98-4
2,2,2-trifluoro-N-(4-(1-methyl-1H-indol-3-yl)-3-(3,4,5-trimethoxyphenyl)-1H-pyrazol-5-yl)acetamide

Guidance literature:: In acetonitrile; for 16h; Reflux;
DOI:10.1016/j.tet.2011.04.077

Reference yield:

: 120-72-9
indole

: 1313529-98-4
2,2,2-trifluoro-N-(4-(1-methyl-1H-indol-3-yl)-3-(3,4,5-trimethoxyphenyl)-1H-pyrazol-5-yl)acetamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: zinc(II) chloride / ethanol / 2 h / 20 °C

2.1: methyl iodide / methanol; water / 16 h / 20 °C

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 20 °C

3.2: 0 - 20 °C

4.1: lithium diisopropyl amide / tetrahydrofuran / 2 h / -78 °C / Inert atmosphere

4.2: -78 - 20 °C / Inert atmosphere

5.1: camphoric acid; hydrazine hydrate / methanol / 23 h / Reflux

6.1: acetonitrile / 16 h / Reflux

With camphoric acid; sodium hydride; hydrazine hydrate; zinc(II) chloride; lithium diisopropyl amide; methyl iodide; In tetrahydrofuran; methanol; ethanol; water; N,N-dimethyl-formamide; acetonitrile; mineral oil; 1.1: Mannich reaction;
DOI:10.1016/j.tet.2011.04.077

Reference yield:

: 771-51-7
indole-3-acetonitrile

: 1313529-98-4
2,2,2-trifluoro-N-(4-(1-methyl-1H-indol-3-yl)-3-(3,4,5-trimethoxyphenyl)-1H-pyrazol-5-yl)acetamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 20 °C

1.2: 0 - 20 °C

2.1: lithium diisopropyl amide / tetrahydrofuran / 2 h / -78 °C / Inert atmosphere

2.2: -78 - 20 °C / Inert atmosphere

3.1: camphoric acid; hydrazine hydrate / methanol / 23 h / Reflux

4.1: acetonitrile / 16 h / Reflux

With camphoric acid; sodium hydride; hydrazine hydrate; lithium diisopropyl amide; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; acetonitrile; mineral oil;
DOI:10.1016/j.tet.2011.04.077