4-(1-methyl-1H-indol-3-yl)-3-(3,4,5-trimethoxyphenyl)-1H-pyrazol-5-amine

Base Information

Chemical Name:4-(1-methyl-1H-indol-3-yl)-3-(3,4,5-trimethoxyphenyl)-1H-pyrazol-5-amine
CAS No.:1313529-92-8
Molecular Formula:C₂₁H₂₂N₄O₃
Molecular Weight:378.431
Hs Code.:

Synonyms:4-(1-methyl-1H-indol-3-yl)-3-(3,4,5-trimethoxyphenyl)-1H-pyrazol-5-amine

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Chemical Property of 4-(1-methyl-1H-indol-3-yl)-3-(3,4,5-trimethoxyphenyl)-1H-pyrazol-5-amine

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Technology Process of 4-(1-methyl-1H-indol-3-yl)-3-(3,4,5-trimethoxyphenyl)-1H-pyrazol-5-amine

There total 7 articles about 4-(1-methyl-1H-indol-3-yl)-3-(3,4,5-trimethoxyphenyl)-1H-pyrazol-5-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 1313529-96-2
2-(1-methyl-1H-indol-3-yl)-3-oxo-3-(3,4,5-trimethoxyphenyl)propanenitrile

: 1313529-92-8
4-(1-methyl-1H-indol-3-yl)-3-(3,4,5-trimethoxyphenyl)-1H-pyrazol-5-amine

Guidance literature:: With camphoric acid; hydrazine hydrate; In methanol; for 23h; Reflux;
DOI:10.1016/j.tet.2011.04.077

Reference yield:

: 120-72-9
indole

: 1313529-92-8
4-(1-methyl-1H-indol-3-yl)-3-(3,4,5-trimethoxyphenyl)-1H-pyrazol-5-amine

Guidance literature:: Multi-step reaction with 5 steps

1.1: zinc(II) chloride / ethanol / 2 h / 20 °C

2.1: methyl iodide / methanol; water / 16 h / 20 °C

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 20 °C

3.2: 0 - 20 °C

4.1: lithium diisopropyl amide / tetrahydrofuran / 2 h / -78 °C / Inert atmosphere

4.2: -78 - 20 °C / Inert atmosphere

5.1: camphoric acid; hydrazine hydrate / methanol / 23 h / Reflux

With camphoric acid; sodium hydride; hydrazine hydrate; zinc(II) chloride; lithium diisopropyl amide; methyl iodide; In tetrahydrofuran; methanol; ethanol; water; N,N-dimethyl-formamide; mineral oil; 1.1: Mannich reaction;
DOI:10.1016/j.tet.2011.04.077

Reference yield:

: 51584-17-9
1-methyl-1H-indole-3-acetonitrile

: 1313529-92-8
4-(1-methyl-1H-indol-3-yl)-3-(3,4,5-trimethoxyphenyl)-1H-pyrazol-5-amine

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium diisopropyl amide / tetrahydrofuran / 2 h / -78 °C / Inert atmosphere

1.2: -78 - 20 °C / Inert atmosphere

2.1: camphoric acid; hydrazine hydrate / methanol / 23 h / Reflux

With camphoric acid; hydrazine hydrate; lithium diisopropyl amide; In tetrahydrofuran; methanol;
DOI:10.1016/j.tet.2011.04.077