Technology Process of ethyl 3-(4-methoxyphenyl)furan-2-carboxylate
There total 2 articles about ethyl 3-(4-methoxyphenyl)furan-2-carboxylate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Ethyl 2-furoate;
With
lithium chlorozincate; 2,2,6,6-tetramethylpiperidinyl-lithium;
In
tetrahydrofuran;
at 0 ℃;
for 0.0111111h;
Flow reactor;
Inert atmosphere;
para-iodoanisole;
With
trifuran-2-yl-phosphane; bis(dibenzylideneacetone)-palladium(0);
In
tetrahydrofuran;
at 25 ℃;
for 2h;
regioselective reaction;
Flow reactor;
Inert atmosphere;
DOI:10.1002/anie.201502393
- Guidance literature:
-
With
tetrakis(triphenylphosphine) palladium(0); caesium carbonate;
In
tetrahydrofuran; water;
Reflux;
DOI:10.1016/j.bmcl.2014.07.025
- Guidance literature:
-
Multi-step reaction with 3 steps
1: hydrazine hydrate / ethanol / Reflux
2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 20 °C
3: sodium hydroxide; water / methanol / 20 °C
With
water; hydrazine hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide;
In
methanol; ethanol; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2014.07.025
