ethyl 5-benzoyl-1-(3-(tert-butyl)-5-(1-methylcyclopropyl)phenyl)-4-methyl-1H-pyrrole-3-carboxylate

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Chemical Name:ethyl 5-benzoyl-1-(3-(tert-butyl)-5-(1-methylcyclopropyl)phenyl)-4-methyl-1H-pyrrole-3-carboxylate
CAS No.:1561966-21-9
Molecular Formula:C₂₉H₃₃NO₃
Molecular Weight:443.586
Hs Code.:

Synonyms:ethyl 5-benzoyl-1-(3-(tert-butyl)-5-(1-methylcyclopropyl)phenyl)-4-methyl-1H-pyrrole-3-carboxylate

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Chemical Property of ethyl 5-benzoyl-1-(3-(tert-butyl)-5-(1-methylcyclopropyl)phenyl)-4-methyl-1H-pyrrole-3-carboxylate

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Technology Process of ethyl 5-benzoyl-1-(3-(tert-butyl)-5-(1-methylcyclopropyl)phenyl)-4-methyl-1H-pyrrole-3-carboxylate

There total 8 articles about ethyl 5-benzoyl-1-(3-(tert-butyl)-5-(1-methylcyclopropyl)phenyl)-4-methyl-1H-pyrrole-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 32.0%

: ethyl 5-benzoyl-4-methyl-1H-pyrrole-3-carboxylate

: 1403387-37-0
1-bromo-3-(tert-butyl)-5-(1-methylcyclopropyl)benzene

: 1561966-21-9
ethyl 5-benzoyl-1-(3-(tert-butyl)-5-(1-methylcyclopropyl)phenyl)-4-methyl-1H-pyrrole-3-carboxylate

Guidance literature:: With potassium phosphate; copper(l) iodide; (R,R)-N,N'-dimethyl-1,2-diaminocyclohexane; In toluene; for 48h; Reflux;

Reference yield:

: 6339-66-8
ethyl 5-formyl-4-methyl-1H-pyrrole-3-carboxylate

: 1561966-21-9
ethyl 5-benzoyl-1-(3-(tert-butyl)-5-(1-methylcyclopropyl)phenyl)-4-methyl-1H-pyrrole-3-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0 - 20 °C

1.2: 20 - 30 °C

2.1: tetrahydrofuran / 0 - 20 °C

3.1: Dess-Martin periodane / dichloromethane / 2 h / 20 °C

4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / Reflux

5.1: potassium phosphate; (R,R)-N,N'-dimethyl-1,2-diaminocyclohexane; copper(l) iodide / toluene / 48 h / Reflux

With potassium phosphate; copper(l) iodide; (R,R)-N,N'-dimethyl-1,2-diaminocyclohexane; tetrabutyl ammonium fluoride; sodium hydride; Dess-Martin periodane; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; toluene; mineral oil;

Reference yield:

: 129316-09-2
1,3-dibromo-5-t-butylbenzene

: 1561966-21-9
ethyl 5-benzoyl-1-(3-(tert-butyl)-5-(1-methylcyclopropyl)phenyl)-4-methyl-1H-pyrrole-3-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; 1,4-dioxane / 90 °C / Inert atmosphere

2.1: trifluoroacetic acid; diethylzinc / hexane; dichloromethane / 0 °C

2.2: 0.5 h / 0 - 20 °C

3.1: potassium phosphate; (R,R)-N,N'-dimethyl-1,2-diaminocyclohexane; copper(l) iodide / toluene / 48 h / Reflux

With potassium phosphate; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; (R,R)-N,N'-dimethyl-1,2-diaminocyclohexane; diethylzinc; potassium carbonate; trifluoroacetic acid; In 1,4-dioxane; hexane; dichloromethane; water; toluene;