5-benzoyl-1-(3-(tert-butyl)-5-(1-methylcyclopropyl)phenyl)-4-methyl-1H-pyrrole-3-carboxylic acid

Base Information

Chemical Name:5-benzoyl-1-(3-(tert-butyl)-5-(1-methylcyclopropyl)phenyl)-4-methyl-1H-pyrrole-3-carboxylic acid
CAS No.:1561966-23-1
Molecular Formula:C₂₇H₂₉NO₃
Molecular Weight:415.532
Hs Code.:

Synonyms:5-benzoyl-1-(3-(tert-butyl)-5-(1-methylcyclopropyl)phenyl)-4-methyl-1H-pyrrole-3-carboxylic acid

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Chemical Property of 5-benzoyl-1-(3-(tert-butyl)-5-(1-methylcyclopropyl)phenyl)-4-methyl-1H-pyrrole-3-carboxylic acid

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Technology Process of 5-benzoyl-1-(3-(tert-butyl)-5-(1-methylcyclopropyl)phenyl)-4-methyl-1H-pyrrole-3-carboxylic acid

There total 10 articles about 5-benzoyl-1-(3-(tert-butyl)-5-(1-methylcyclopropyl)phenyl)-4-methyl-1H-pyrrole-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 1561966-21-9
ethyl 5-benzoyl-1-(3-(tert-butyl)-5-(1-methylcyclopropyl)phenyl)-4-methyl-1H-pyrrole-3-carboxylate

: 1561966-23-1
5-benzoyl-1-(3-(tert-butyl)-5-(1-methylcyclopropyl)phenyl)-4-methyl-1H-pyrrole-3-carboxylic acid

Guidance literature:: With potassium tert-butylate; water; In dimethyl sulfoxide; at 90 ℃;

Reference yield:

: 6339-66-8
ethyl 5-formyl-4-methyl-1H-pyrrole-3-carboxylate

: 1561966-23-1
5-benzoyl-1-(3-(tert-butyl)-5-(1-methylcyclopropyl)phenyl)-4-methyl-1H-pyrrole-3-carboxylic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0 - 20 °C

1.2: 20 - 30 °C

2.1: tetrahydrofuran / 0 - 20 °C

3.1: Dess-Martin periodane / dichloromethane / 2 h / 20 °C

4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / Reflux

5.1: potassium phosphate; (R,R)-N,N'-dimethyl-1,2-diaminocyclohexane; copper(l) iodide / toluene / 48 h / Reflux

6.1: potassium tert-butylate; water / dimethyl sulfoxide / 90 °C

With potassium phosphate; copper(l) iodide; (R,R)-N,N'-dimethyl-1,2-diaminocyclohexane; potassium tert-butylate; tetrabutyl ammonium fluoride; water; sodium hydride; Dess-Martin periodane; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene; mineral oil;

Reference yield:

: 129316-09-2
1,3-dibromo-5-t-butylbenzene

: 1561966-23-1
5-benzoyl-1-(3-(tert-butyl)-5-(1-methylcyclopropyl)phenyl)-4-methyl-1H-pyrrole-3-carboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; 1,4-dioxane / 90 °C / Inert atmosphere

2.1: trifluoroacetic acid; diethylzinc / hexane; dichloromethane / 0 °C

2.2: 0.5 h / 0 - 20 °C

3.1: potassium phosphate; (R,R)-N,N'-dimethyl-1,2-diaminocyclohexane; copper(l) iodide / toluene / 48 h / Reflux

4.1: potassium tert-butylate; water / dimethyl sulfoxide / 90 °C

With potassium phosphate; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; (R,R)-N,N'-dimethyl-1,2-diaminocyclohexane; potassium tert-butylate; water; diethylzinc; potassium carbonate; trifluoroacetic acid; In 1,4-dioxane; hexane; dichloromethane; water; dimethyl sulfoxide; toluene;