Technology Process of Cbz-R-cis-(4aS,8aS)-3-Piq-Pro-OH
There total 6 articles about Cbz-R-cis-(4aS,8aS)-3-Piq-Pro-OH which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
trifluoroacetic acid;
In
dichloromethane;
for 1h;
Ambient temperature;
DOI:10.1021/jm00022a009
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 100 percent / H2, aq.HCl / 5percent Rh/Al2O3 / 16 h / 120 °C / 103430 Torr
2: 85 percent / aq.NaOH / tetrahydrofuran / 2 h / Ambient temperature; pH 9.8
3: 94 percent / HOBt, DCC / dimethylformamide / 1.) 0 deg C, 3 h, 2.) RT, 24 h
4: 49 percent / TFA / CH2Cl2; various solvent(s) / 1 h / Ambient temperature
With
hydrogenchloride; sodium hydroxide; hydrogen; benzotriazol-1-ol; dicyclohexyl-carbodiimide; trifluoroacetic acid;
Rh/Al2O3;
In
tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00022a009
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 94 percent / HOBt, DCC / dimethylformamide / 1.) 0 deg C, 3 h, 2.) RT, 24 h
2: 49 percent / TFA / CH2Cl2; various solvent(s) / 1 h / Ambient temperature
With
benzotriazol-1-ol; dicyclohexyl-carbodiimide; trifluoroacetic acid;
In
dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00022a009
