103733-65-9

Basic information

• Product Name: D-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid
• Synonyms: 1,2,3,4-TETRAHYDROISOQUINOLINE-(3R)-CARBOXYLIC ACID;1,2,3,4-D-TETRAHYDROISOQUINOLINE-3-CARBOXYLIC ACID;3-ISOQUINOLINECARBOXYLIC ACID, 1,2,3,4-TETRAHYDRO-, (3R)-;(3R)-1,2,3,4-TETRAHYDROISOQUINOLINE-3-CARBOXYLIC ACID;H-D-TIC-OH;D-1,2,3,4-TETRAHYDROISOQUINOLINE-3-CARBOXYLIC ACID;D-[3R]-1,2,3,4-TETRAHYDROISOQUINOLINE-3-CARBOXYLIC ACID;D-TIC
• CAS NO: 103733-65-9
• Molecular Formula: C₁₀H₁₁NO₂
• Molecular Weight: 177.2
• EINECS: 266-580-4
• Product Categories: Amino Acids;Others;Peptide Synthesis;Unnatural Amino Acid Derivatives;a-amino
• Mol File: 103733-65-9.mol
• Article Data: 10

Chemical Properties

• Melting Point: 320-323 °C (decomp)
• Boiling Point: 372 ºC at 760 mmHg
• Flash Point: 178.8 ºC
• Appearance: White/Crystalline Powder
• Density: 1.225 g/cm³
• Vapor Pressure: 3.41E-06mmHg at 25°C
• Refractive Index: 1.576
• Storage Temp.: 2-8°C
• Solubility: Aqueous Acid (Slightly), Aqueous Base (Sparingly, Sonicated)
• PKA: 2.21±0.20(Predicted)
• CAS DataBase Reference: D-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: D-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid(103733-65-9)
• EPA Substance Registry System: D-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid(103733-65-9)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 103733-65-9(Hazardous Substances Data)

Usage

Chemical Properties

White solid

Uses

(R)-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic Acid, is an amino acid building block used in peptide synthesis. With a growing peptide drug market the fast, reliable synthesis of peptides is of great importance.

InChI:InChI=1/C10H11NO2/c12-10(13)9-5-7-3-1-2-4-8(7)6-11-9/h1-4,9,11H,5-6H2,(H,12,13)/t9-/m1/s1

Upstream product

• 50-00-0 formaldehyd 
• 673-06-3 D-(R)-phenylalanine 
• 307304-56-9 (3'S,4R,5S)-1,5-dimethyl-4-phenyl-3-(1',2',3',4'-tetrahydro-3'-isoquinolinylcarbonyl)-2-imidazolidinone 
• 307304-64-9 (3'R,4S,5R)-1,5-dimethyl-4-phenyl-3-(1',2',3',4'-tetrahydro-3'-isoquinolinylcarbonyl)-2-imidazolidinone 
• 143767-54-8 (R,S)-2-acetyl-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid 
• 612-12-4 o-Xylylene dichloride 
• 81477-94-3 N-(diphenylmethylene)glycine tert-butyl ester 
• 91-13-4 α,α'-dibromo-o-xylene 
• 115-11-7 isobutene 
• 143767-55-9 dimethyl 2-acetyl-1,2,3,4-tetrahydroisoquinoline-3,3-dicarboxylate 
• 67123-97-1 (R,S)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid 
• 143767-57-1 (-)-menthyl (R)-1,2,3,4-tetrahydroisoquinoline-3-carboxylate 
• 146503-35-7 benzyl (3R)-methyl-1,2,3,4-tetrahydroisoquinoline-3-carboxylate 
• 74163-81-8 L-Tic-OH 

Downstream Products

• 103733-65-9 (R)-1,2,3,4-tetrahydro-3-isoquinolinecarboxylic acid, 1,1-dimethylethyl ester 
• 62855-02-1 (R)-3-hydroxymethyl-1,2,3,4-tetrahydroisoquinoline 
• 1312952-31-0 (3R)-2-(5-((4-butylphenyl)ethynyl)thiophen-2-ylsulfonyl)-N-(tetrahydro-2H-pyran-2-yloxy)-1,2,3,4-tetrahydroisoquinoline-3-carboxamide 
• 1312952-18-3 (3R)-2-(5-((4-butylphenyl)ethynyl)thiophen-2-ylsulfonyl)-N-hydroxy-1,2,3,4-tetrahydroisoquinoline-3-carboxamide 
• 845543-81-9 tert-butyl (3R)-3-(hydroxymethyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate 
• 444583-19-1 tert-butyl (3R)-3-formyl-3,4-dihydroisoquinoline-2(1H)-carboxylate 
• 191326-92-8 (3R)-N-(4-biphenylylsulfonyl)-1,2,3,4-tetrahydro-3-isoquinolinecarboxylic acid 
• 77708-84-0 N-(3'-Acetylthio-2'-methylpropanoyl)-L-(1,2,3,4-tetrahydroisoquinoline)-3-carboxylic acid 
• 77708-84-0 (S)-2-(3-Acetylsulfanyl-2-methyl-propionyl)-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid 
• 115732-14-4 N-benzoyl-D-3-carboxy-1,2,3,4-tetrahydroisoquinoline 

Relevant articles and documents

Characterization of a selective inhibitor for matrix metalloproteinase-8 (MMP-8)

MMP-8 has been implicated in various diseases. Selective MMP-8 inhibitors are needed to ascertain the role of this enzyme. We synthesized two inhibitors reported previously as selective for MMP-8. Compound 1 selectively inhibited MMP-8 and MMP-13; compoun

Concise, catalytic asymmetric synthesis of tetrahydroisoquinoline- and dihydroisoquinoline-3-carboxylic acid derivatives

Catalytic asymmetric synthesis of tetrahydroisoquinoline-3-carboxylic acid (Tic) derivatives 1 has been accomplished by the successful utilization of phase-transfer catalysis of the C2-symmetric chiral quaternary ammonium bromides. Our approach also enables facile synthesis of quaternary isoquinoline derivatives 2 and 3 with high enantiomeric purities.

ANTIPARASITIC TERPENE ALKALOIDS

The present invention relates to novel terpene alkaloids and their use as antiparasitic agents. The present invention also relates to an antiparasitic agent which comprises a terpene alkaloid compound of this invention as an effective ingredient in an antiparasitic formulation. More particularly, the present invention relates to derivatives of the terpene alkaloid (1S,2R,4aS,5R,8R,8aR)-2-(acetyloxy)-8a-hydroxy-3,8-dimethyl-5-(1-methylethenyl)-1,2,4a,5,6,7,8,8a-octahydronaphthalen-1-yl (2S,3aR,9bR)-6-chloro-9b-hydroxy-5-methyl-1,2,3,3a,5,9b-hexahydropyrrolo[2,3-c][2,1]benzoxazine-2-carboxylate. Pharmaceutical compositions comprising the same are also disclosed.