di-tert-butyl 1-((1R,5R,6S)-5,6-dihydroxycyclohex-2-enyl)hydrazine-1,2-dicarboxylate

Base Information

• Chemical Name: di-tert-butyl 1-((1R,5R,6S)-5,6-dihydroxycyclohex-2-enyl)hydrazine-1,2-dicarboxylate
• CAS No.: 1161437-09-7
• Molecular Formula: C₁₆H₂₈N₂O₆
• Molecular Weight: 344.408
• Mol file: 1161437-09-7.mol

Synonyms:di-tert-butyl 1-((1R,5R,6S)-5,6-dihydroxycyclohex-2-enyl)hydrazine-1,2-dicarboxylate

Chemical Property of di-tert-butyl 1-((1R,5R,6S)-5,6-dihydroxycyclohex-2-enyl)hydrazine-1,2-dicarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of di-tert-butyl 1-((1R,5R,6S)-5,6-dihydroxycyclohex-2-enyl)hydrazine-1,2-dicarboxylate

There total 1 articles about di-tert-butyl 1-((1R,5R,6S)-5,6-dihydroxycyclohex-2-enyl)hydrazine-1,2-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

di-tert-butyl 1-(cyclohexa-2,5-dienyl)hydrazine-1,2-dicarboxylate (1161437-07-5) → di-tert-butyl 1-((1R,5R,6S)-5,6-dihydroxycyclohex-2-enyl)hydrazine-1,2-dicarboxylate (1161437-09-7) + di-tert-butyl 1-((1S,5S,6R)-5,6-dihydroxycyclohex-2-enyl)hydrazine-1,2-dicarboxylate

Guidance literature:

di-tert-butyl 1-(cyclohexa-2,5-dienyl)hydrazine-1,2-dicarboxylate; With methanesulfonamide; AD-mix β; In tetrahydrofuran; water; at 0 ℃; for 24h;

With sodium sulfite; In tetrahydrofuran; water; at 20 ℃; for 0.5h; optical yield given as %ee; diastereoselective reaction;

DOI:10.1021/ol900779v

Reference yield: 100.0%

di-tert-butyl 1-((1R,5R,6S)-5,6-dihydroxycyclohex-2-enyl)hydrazine-1,2-dicarboxylate (1161437-09-7) → (1R,2S,3R)-3-hydrazinylcyclohex-4-ene-1,2-diol hydrochloride (1161437-11-1)

Guidance literature:

With hydrogenchloride; In ethyl acetate; at 0 - 20 ℃;

DOI:10.1021/ol900779v

upstream raw materials:

di-tert-butyl 1-(cyclohexa-2,5-dienyl)hydrazine-1,2-dicarboxylate

Downstream raw materials:

(1R,2S,3R)-3-hydrazinylcyclohex-4-ene-1,2-diol hydrochloride