N-(3-hydroxy-3-(1-tosyl-1H-indol-2-yl)propyl)-N-(4-hydroxybenzyl)-4-methylbenzenesulfonamide

Base Information

Chemical Name:N-(3-hydroxy-3-(1-tosyl-1H-indol-2-yl)propyl)-N-(4-hydroxybenzyl)-4-methylbenzenesulfonamide
CAS No.:1579268-52-2
Molecular Formula:C₃₂H₃₂N₂O₆S₂
Molecular Weight:604.748
Hs Code.:

Synonyms:N-(3-hydroxy-3-(1-tosyl-1H-indol-2-yl)propyl)-N-(4-hydroxybenzyl)-4-methylbenzenesulfonamide

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Chemical Property of N-(3-hydroxy-3-(1-tosyl-1H-indol-2-yl)propyl)-N-(4-hydroxybenzyl)-4-methylbenzenesulfonamide

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Technology Process of N-(3-hydroxy-3-(1-tosyl-1H-indol-2-yl)propyl)-N-(4-hydroxybenzyl)-4-methylbenzenesulfonamide

There total 3 articles about N-(3-hydroxy-3-(1-tosyl-1H-indol-2-yl)propyl)-N-(4-hydroxybenzyl)-4-methylbenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 1579268-50-0
N-(4-((tert-butyldimethylsilyl)oxy)benzyl)-N-(3-hydroxy-3-(1-tosyl-1H-indol-2-yl)propyl)-4-methylbenzenesulfonamide

: 1579268-52-2
N-(3-hydroxy-3-(1-tosyl-1H-indol-2-yl)propyl)-N-(4-hydroxybenzyl)-4-methylbenzenesulfonamide

Guidance literature:: With tetrabutyl ammonium fluoride; acetic acid; In tetrahydrofuran; at 0 ℃; for 0.0833333h;
DOI:10.1016/j.tet.2014.01.074

Reference yield:

: 1424888-75-4
C₂₅H₃₈N₂O₅SSi

: 1579268-52-2
N-(3-hydroxy-3-(1-tosyl-1H-indol-2-yl)propyl)-N-(4-hydroxybenzyl)-4-methylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: diisobutylaluminium hydride / dichloromethane; hexane / 0.33 h / -78 °C

2.1: isopropylmagnesium chloride / tetrahydrofuran / 0.5 h / 0 °C

2.2: 0.67 h / 0 °C

3.1: acetic acid; tetrabutyl ammonium fluoride / tetrahydrofuran / 0.08 h / 0 °C

With tetrabutyl ammonium fluoride; isopropylmagnesium chloride; diisobutylaluminium hydride; acetic acid; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1016/j.tet.2014.01.074

Reference yield:

: C₂₃H₃₃NO₄SSi

: 1579268-52-2
N-(3-hydroxy-3-(1-tosyl-1H-indol-2-yl)propyl)-N-(4-hydroxybenzyl)-4-methylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: isopropylmagnesium chloride / tetrahydrofuran / 0.5 h / 0 °C

1.2: 0.67 h / 0 °C

2.1: acetic acid; tetrabutyl ammonium fluoride / tetrahydrofuran / 0.08 h / 0 °C

With tetrabutyl ammonium fluoride; isopropylmagnesium chloride; acetic acid; In tetrahydrofuran;
DOI:10.1016/j.tet.2014.01.074