(S)-methyl 6-[2-(benzoylamino)acetamido]-2-[(4-trifluoromethyl)-benzyloxycarbonylamino]hexanoate

Base Information

Chemical Name:(S)-methyl 6-[2-(benzoylamino)acetamido]-2-[(4-trifluoromethyl)-benzyloxycarbonylamino]hexanoate
CAS No.:331714-11-5
Molecular Formula:C₂₅H₂₈F₃N₃O₆
Molecular Weight:523.509
Hs Code.:

Synonyms:(S)-methyl 6-[2-(benzoylamino)acetamido]-2-[(4-trifluoromethyl)-benzyloxycarbonylamino]hexanoate

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Chemical Property of (S)-methyl 6-[2-(benzoylamino)acetamido]-2-[(4-trifluoromethyl)-benzyloxycarbonylamino]hexanoate

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Technology Process of (S)-methyl 6-[2-(benzoylamino)acetamido]-2-[(4-trifluoromethyl)-benzyloxycarbonylamino]hexanoate

There total 6 articles about (S)-methyl 6-[2-(benzoylamino)acetamido]-2-[(4-trifluoromethyl)-benzyloxycarbonylamino]hexanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 98-88-4
benzoyl chloride

: (S)-methyl 6-[2-(amino)acetamido]-2-[(4-trifluoromethyl)benzyloxycarbonylamino]hexanoate hydrochloride

: 331714-11-5
(S)-methyl 6-[2-(benzoylamino)acetamido]-2-[(4-trifluoromethyl)-benzyloxycarbonylamino]hexanoate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 25 ℃; for 2h;
DOI:10.1021/ja003579+

Reference yield:

: 349-95-1
4-(trifluoromethyl)benzylic alcohol

: 331714-11-5
(S)-methyl 6-[2-(benzoylamino)acetamido]-2-[(4-trifluoromethyl)-benzyloxycarbonylamino]hexanoate

Guidance literature:: Multi-step reaction with 6 steps

1: Et₃N / acetonitrile / 3 h / 25 °C

2: 6.4 g / acetonitrile / 3 h / 25 °C

3: HCl / dioxane; CH₂Cl₂ / 0.33 h / 25 °C

4: 2.89 g / EDCI; i-Pr₂NEt / dimethylformamide / 12 h / 25 °C

5: 99 percent / aq. HCl / dioxane; CH₂Cl₂ / 1 h / 25 °C

6: 40 mg / i-Pr₂NEt / CH₂Cl₂ / 2 h / 25 °C

With hydrogenchloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/ja003579+

Reference yield:

: 332378-22-0
carbonic acid 2,5-dioxo-pyrrolidin-1-yl ester 4-trifluoromethyl-benzyl ester

: 331714-11-5
(S)-methyl 6-[2-(benzoylamino)acetamido]-2-[(4-trifluoromethyl)-benzyloxycarbonylamino]hexanoate

Guidance literature:: Multi-step reaction with 5 steps

1: 6.4 g / acetonitrile / 3 h / 25 °C

2: HCl / dioxane; CH₂Cl₂ / 0.33 h / 25 °C

3: 2.89 g / EDCI; i-Pr₂NEt / dimethylformamide / 12 h / 25 °C

4: 99 percent / aq. HCl / dioxane; CH₂Cl₂ / 1 h / 25 °C

5: 40 mg / i-Pr₂NEt / CH₂Cl₂ / 2 h / 25 °C

With hydrogenchloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/ja003579+