3-tert-butyl-N-(4-(aminomethyl)thiazol-2-yl)-1-benzyl-1H-pyrazole-5-carboxamide

Base Information

• Chemical Name: 3-tert-butyl-N-(4-(aminomethyl)thiazol-2-yl)-1-benzyl-1H-pyrazole-5-carboxamide
• CAS No.: 1341128-82-2
• Molecular Formula: C₁₉H₂₃N₅OS
• Molecular Weight: 369.491
• Mol file: 1341128-82-2.mol

Synonyms:3-tert-butyl-N-(4-(aminomethyl)thiazol-2-yl)-1-benzyl-1H-pyrazole-5-carboxamide

Chemical Property of 3-tert-butyl-N-(4-(aminomethyl)thiazol-2-yl)-1-benzyl-1H-pyrazole-5-carboxamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-tert-butyl-N-(4-(aminomethyl)thiazol-2-yl)-1-benzyl-1H-pyrazole-5-carboxamide

There total 3 articles about 3-tert-butyl-N-(4-(aminomethyl)thiazol-2-yl)-1-benzyl-1H-pyrazole-5-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-benzyl-3-(tert-butyl)-1H-pyrazole-5-carboxylic acid (100957-85-5) → 3-tert-butyl-N-(4-(aminomethyl)thiazol-2-yl)-1-benzyl-1H-pyrazole-5-carboxamide (1341128-82-2)

Guidance literature:

Multi-step reaction with 3 steps

1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

2: sodium azide / N,N-dimethyl-formamide / 24 h / 80 °C

3: triphenylphosphine / tetrahydrofuran; water / 24 h

With sodium azide; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; triphenylphosphine; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide;

DOI:10.1021/jm201108k

Reference yield:

1-benzyl-3-tert-butyl-N-(4-chloromethylthiazol-2-yl)-1H-pyrazole-5-carboxamide (1341129-03-0) → 3-tert-butyl-N-(4-(aminomethyl)thiazol-2-yl)-1-benzyl-1H-pyrazole-5-carboxamide (1341128-82-2)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium azide / N,N-dimethyl-formamide / 24 h / 80 °C

2: triphenylphosphine / tetrahydrofuran; water / 24 h

With sodium azide; triphenylphosphine; In tetrahydrofuran; water; N,N-dimethyl-formamide;

DOI:10.1021/jm201108k

Reference yield:

3-tert-butyl-N-(4-(azidomethyl)thiazol-2-yl)-1-benzyl-1H-pyrazole-5-carboxamide → 3-tert-butyl-N-(4-(aminomethyl)thiazol-2-yl)-1-benzyl-1H-pyrazole-5-carboxamide (1341128-82-2)

Guidance literature:

With triphenylphosphine; In tetrahydrofuran; water; for 24h;

DOI:10.1021/jm201108k

upstream raw materials:

1-benzyl-3-tert-butyl-N-(4-chloromethylthiazol-2-yl)-1H-pyrazole-5-carboxamide

1-benzyl-3-(tert-butyl)-1H-pyrazole-5-carboxylic acid

Downstream raw materials:

3-tert-butyl-N-(4-(acetamidomethyl)thiazol-2-yl)-1-benzyl-1H-pyrazole-5-carboxamide

3-tert-butyl-1-benzyl-N-{4-[(methanesulfonamido)methyl]thiazol-2-yl}-1H-pyrazole-5-carboxamide