1-(3-phenylprop-1-yn-1-yl)cyclopropanecarbaldehyde

Base Information

Chemical Name:1-(3-phenylprop-1-yn-1-yl)cyclopropanecarbaldehyde
CAS No.:1646541-01-6
Molecular Formula:C₁₃H₁₂O
Molecular Weight:184.238
Hs Code.:

Synonyms:1-(3-phenylprop-1-yn-1-yl)cyclopropanecarbaldehyde

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Chemical Property of 1-(3-phenylprop-1-yn-1-yl)cyclopropanecarbaldehyde

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Technology Process of 1-(3-phenylprop-1-yn-1-yl)cyclopropanecarbaldehyde

There total 8 articles about 1-(3-phenylprop-1-yn-1-yl)cyclopropanecarbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1646541-08-3
C₁₃H₁₄O

: 1646541-01-6
1-(3-phenylprop-1-yn-1-yl)cyclopropanecarbaldehyde

Guidance literature:: With 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In dimethyl sulfoxide; at 20 ℃;
DOI:10.1002/anie.201405215

Reference yield:

: 6746-94-7
Cyclopropylacetylene

: 1646541-01-6
1-(3-phenylprop-1-yn-1-yl)cyclopropanecarbaldehyde

Guidance literature:: Multi-step reaction with 8 steps

1.1: n-butyllithium / tetrahydrofuran / -78 °C

2.1: n-butyllithium / diethyl ether / 0 - 20 °C

3.1: potassium carbonate; methanol / 2 h / 20 °C

4.1: sodium tetrahydroborate / methanol

5.1: 1H-imidazole / dichloromethane / 4 h / 0 - 20 °C / Inert atmosphere

6.1: n-butyllithium; sodium iodide / tetrahydrofuran / 2 h / -78 °C / Inert atmosphere

6.2: 10 h / 50 °C / Inert atmosphere

7.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 5 h / 20 °C / Inert atmosphere

8.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / dimethyl sulfoxide / 20 °C

With 1H-imidazole; methanol; sodium tetrahydroborate; n-butyllithium; tetrabutyl ammonium fluoride; potassium carbonate; sodium iodide; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; dimethyl sulfoxide;
DOI:10.1002/anie.201405215

Reference yield:

: 81166-84-9
(2-cyclopropylethynyl)trimethylsilane

: 1646541-01-6
1-(3-phenylprop-1-yn-1-yl)cyclopropanecarbaldehyde

Guidance literature:: Multi-step reaction with 7 steps

1.1: n-butyllithium / diethyl ether / 0 - 20 °C

2.1: potassium carbonate; methanol / 2 h / 20 °C

3.1: sodium tetrahydroborate / methanol

4.1: 1H-imidazole / dichloromethane / 4 h / 0 - 20 °C / Inert atmosphere

5.1: n-butyllithium; sodium iodide / tetrahydrofuran / 2 h / -78 °C / Inert atmosphere

5.2: 10 h / 50 °C / Inert atmosphere

6.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 5 h / 20 °C / Inert atmosphere

7.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / dimethyl sulfoxide / 20 °C

With 1H-imidazole; methanol; sodium tetrahydroborate; n-butyllithium; tetrabutyl ammonium fluoride; potassium carbonate; sodium iodide; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; dimethyl sulfoxide;
DOI:10.1002/anie.201405215