81166-84-9Relevant articles and documents
Ynonylation of Acyl Radicals by Electroinduced Homolysis of 4-Acyl-1,4-dihydropyridines
Luo, Xiaosheng,Wang, Ping
supporting information, p. 4960 - 4965 (2021/07/20)
Herein we report the conversion of 4-Acyl-1,4-dihydropyridines (DHPs) into ynones under electrochemical conditions. The reaction proceeds via the homolysis of acyl-DHP under electron activation. The resulting acyl radicals react with hypervalent iodine(III) reagents to form the target ynones or ynamides in acceptable yields. This mild reaction condition allows wider functionality tolerance that includes halides, carboxylates, or alkenes. The synthetic utility of this methodology is further demonstrated by the late-stage modification of complex molecules.
Preparation method for compound containing alkynyl and cyclopropyl
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Paragraph 0024; 0025; 0026; 0027; 0028, (2018/03/07)
The invention relates to the field of organic synthesis, and discloses a preparation method for a compound containing alkynyl and cyclopropyl. The method comprises the following steps: a compound ii with alkyne and alkene is taken as a starting raw material, under effects of a catalyst, the compound ii with the alkyne and the alkene and a diazo substance iv are mixed and reacted in a solvent, andtherefore a reaction liquid containing a compound iii is obtained; and the obtained reaction liquid is added into acid water or hot water for washing, then an inorganic alkali or an organic alkali isadded to adjust the pH to 8-14, and therefore the compound I containing the alkynyl and the cyclopropyl is obtained. The method provided by the invention has the following beneficial effects: 1) the yield of the reaction is improved; 2) the industrialized raw materials used by the method are cheap and easy to obtain; and 3) by-products are reduced, and environmental pollution is reduced.
Gold(i)-catalyzed dehydrogenative cycloisomerization of 1,5-enynes
Chen, Gen-Qiang,Fang, Wei,Wei, Yin,Tang, Xiang-Ying,Shi, Min
supporting information, p. 10799 - 10802 (2016/09/07)
The gold(i)-catalyzed dehydrogenative cycloisomerization of cyclopropane-tethered 1,5-enynes proceeded smoothly to give multisubstituted benzene derivatives in good to excellent yields. Synthetically important benzocyclobutenes can be produced in high yields in the presence of a gold(i) catalyst and DDQ. Furthermore, this reaction also works very well for non-cyclopropane tethered 1,5-enynes.
