(S)-2-(5-(tert-butyl)thiophene-2-carboxamido)-3-(4-(5-(4-(decyloxy)phenyl)-pyrimidin-2-yl)phenyl)propanoic acid

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Chemical Name:(S)-2-(5-(tert-butyl)thiophene-2-carboxamido)-3-(4-(5-(4-(decyloxy)phenyl)-pyrimidin-2-yl)phenyl)propanoic acid
CAS No.:1443790-55-3
Molecular Formula:C₃₈H₄₇N₃O₄S
Molecular Weight:641.875
Hs Code.:

Synonyms:(S)-2-(5-(tert-butyl)thiophene-2-carboxamido)-3-(4-(5-(4-(decyloxy)phenyl)-pyrimidin-2-yl)phenyl)propanoic acid

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Chemical Property of (S)-2-(5-(tert-butyl)thiophene-2-carboxamido)-3-(4-(5-(4-(decyloxy)phenyl)-pyrimidin-2-yl)phenyl)propanoic acid

Chemical Property:

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Technology Process of (S)-2-(5-(tert-butyl)thiophene-2-carboxamido)-3-(4-(5-(4-(decyloxy)phenyl)-pyrimidin-2-yl)phenyl)propanoic acid

There total 9 articles about (S)-2-(5-(tert-butyl)thiophene-2-carboxamido)-3-(4-(5-(4-(decyloxy)phenyl)-pyrimidin-2-yl)phenyl)propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (S)-2-(5-(tert-butyl)thiophene-2-carboxamido)-3-(4-(5-(4-(decyloxy)phenyl)pyrimidin-2-yl)phenyl)propanoate

: 1443790-55-3
(S)-2-(5-(tert-butyl)thiophene-2-carboxamido)-3-(4-(5-(4-(decyloxy)phenyl)-pyrimidin-2-yl)phenyl)propanoic acid

Guidance literature:: In dichloromethane;

Reference yield:

: 29212-25-7
5-(tert-butyl)thiophene-2-carboxylic acid

: 1443790-55-3
(S)-2-(5-(tert-butyl)thiophene-2-carboxamido)-3-(4-(5-(4-(decyloxy)phenyl)-pyrimidin-2-yl)phenyl)propanoic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: triethylamine; HATU / N,N-dimethyl-formamide / 0.5 h / 20 °C

1.2: 1 h

2.1: N-ethyl-N,N-diisopropylamine / 18 h

3.1: potassium acetate; palladium bis[bis(diphenylphosphino)ferrocene] dichloride / dimethyl sulfoxide / 18 h / 100 °C / Inert atmosphere

4.1: palladium bis[bis(diphenylphosphino)ferrocene] dichloride; sodium hydrogencarbonate / water; tetrahydrofuran; acetonitrile / 1 h / 120 °C / Microwave irradiation

5.1: palladium bis[bis(diphenylphosphino)ferrocene] dichloride; sodium carbonate / water; tetrahydrofuran; acetonitrile / 0.75 h / 110 °C / Microwave irradiation

6.1: potassium carbonate / N,N-dimethyl-formamide / 18 h / 40 °C

7.1: dichloromethane

With palladium bis[bis(diphenylphosphino)ferrocene] dichloride; potassium acetate; sodium hydrogencarbonate; sodium carbonate; potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; In tetrahydrofuran; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1443792-18-4
tert-butyl (S)-2-(5-(tert-butyl)thiophene-2-carboxamido)-3-(4-(((trifluoromethyl)sulfonyl)oxy)phenyl)propanoate

: 1443790-55-3
(S)-2-(5-(tert-butyl)thiophene-2-carboxamido)-3-(4-(5-(4-(decyloxy)phenyl)-pyrimidin-2-yl)phenyl)propanoic acid

Guidance literature:: Multi-step reaction with 5 steps

1: potassium acetate; palladium bis[bis(diphenylphosphino)ferrocene] dichloride / dimethyl sulfoxide / 18 h / 100 °C / Inert atmosphere

2: palladium bis[bis(diphenylphosphino)ferrocene] dichloride; sodium hydrogencarbonate / water; tetrahydrofuran; acetonitrile / 1 h / 120 °C / Microwave irradiation

3: palladium bis[bis(diphenylphosphino)ferrocene] dichloride; sodium carbonate / water; tetrahydrofuran; acetonitrile / 0.75 h / 110 °C / Microwave irradiation

4: potassium carbonate / N,N-dimethyl-formamide / 18 h / 40 °C

5: dichloromethane

With palladium bis[bis(diphenylphosphino)ferrocene] dichloride; potassium acetate; sodium hydrogencarbonate; sodium carbonate; potassium carbonate; In tetrahydrofuran; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; acetonitrile;