5-Tert-butylthiophene-2-carboxylic acid

Base Information

Chemical Name:5-Tert-butylthiophene-2-carboxylic acid
CAS No.:29212-25-7
Molecular Formula:C9H12O2S
Molecular Weight:184.259
Hs Code.:2934999090
European Community (EC) Number:674-945-8,674-948-4
DSSTox Substance ID:DTXSID30332503
Wikidata:Q82097183
ChEMBL ID:CHEMBL4285304
Mol file:29212-25-7.mol

Synonyms:5-tert-butylthiophene-2-carboxylic acid;29212-25-7;5-tert-Butyl-thiophene-2-carboxylic acid;478022-18-3;5-(tert-butyl)thiophene-2-carboxylic acid;2-Thiophenecarboxylic acid, 5-(1,1-dimethylethyl)-;CHEMBL4285304;5-TERT-BUTYL-THIOPHENE-2-CARBOXYLICACID;SCHEMBL335624;DTXSID30332503;AMY37739;BDBM50467720;GEO-03234;MFCD01566583;STK351004;AKOS000313577;FS-1672;5-tert-Butyl-2-thiophenecarboxylic acid;NCGC00335762-01;2-Thiophenecarboxylic acid, 5-tert-butyl-;5-tert-Butyl-2-thiophenecarboxylic acid #;CS-0062487;FT-0753481;EN300-109496;AB01328526-02;5-(1,1-dimethylethyl)-2-thiophenecarboxylic acid;A819813;5-tert-Butyl-thiophene-2-carboxylic acid, AldrichCPR;Z431535920

Suppliers and Price of 5-Tert-butylthiophene-2-carboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
5-tert-butylthiophene-2-carboxylicAcid
100mg
$ 60.00

SynQuest Laboratories
5-(tert-Butyl)thiophene-2-carboxylic acid
25 g
$ 592.00

SynQuest Laboratories
5-(tert-Butyl)thiophene-2-carboxylic acid
1 g
$ 50.00

Matrix Scientific
5-tert-Butylthiophene-2-carboxylic acid
1g
$ 124.00

Matrix Scientific
5-tert-Butylthiophene-2-carboxylic acid
5g
$ 418.00

Crysdot
5-tert-Butyl-thiophene-2-carboxylicacid 95+%
25g
$ 377.00

Chemenu
5-tert-Butyl-thiophene-2-carboxylicacid 95%
25g
$ 356.00

Arctom
5-tert-Butyl-thiophene-2-carboxylicacid 98%
1g
$ 81.00

Arctom
5-tert-Butyl-thiophene-2-carboxylicacid 98%
25g
$ 716.00

Arctom
5-tert-Butyl-thiophene-2-carboxylicacid 98%
5g
$ 240.00

Total 14 raw suppliers

Chemical Property of 5-Tert-butylthiophene-2-carboxylic acid

Chemical Property:

Vapor Pressure:0.0138mmHg at 25°C
Melting Point:124-125 °C
Boiling Point:258.3oC at 760 mmHg
PKA:3.74±0.10(Predicted)
Flash Point:110oC
PSA：65.54000
Density:1.178g/cm3
LogP:2.74380
XLogP3:3.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:184.05580079
Heavy Atom Count:12
Complexity:184

Purity/Quality:

99%, ^*data from raw suppliers

5-tert-butylthiophene-2-carboxylicAcid ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)(C)C1=CC=C(S1)C(=O)O

Technology Process of 5-Tert-butylthiophene-2-carboxylic acid

There total 10 articles about 5-Tert-butylthiophene-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 229003-19-4
methyl 5-(tert-butyl)thiophene-2-carboxylate

: 29212-25-7
5-(tert-butyl)thiophene-2-carboxylic acid

Guidance literature:: methyl 5-(tert-butyl)thiophene-2-carboxylate; With methanol; potassium hydroxide; water; for 3h; Heating / reflux;

With hydrogenchloride; In water; ethyl acetate; pH=~ 3;

Reference yield: 46.0%

: 527-72-0
2-thiophenylcarboxylic acid

: 507-19-7
t-butyl bromide

: 29212-25-7
5-(tert-butyl)thiophene-2-carboxylic acid

Guidance literature:: With aluminium trichloride; In dichloromethane; for 18h; Ambient temperature;
DOI:10.1021/jm970038v

Reference yield:

: 1689-78-7
2-tert-butylthiophene

: 29212-25-7
5-(tert-butyl)thiophene-2-carboxylic acid

Guidance literature:: With diethyl ether; chloroethane; sodium; Behandeln des Reaktionsgemisches mit festem Kohlendioxid;
DOI:10.1021/ja01184a100