2-(trimethylsilyl)ethyl 1-benzoyl-3-methyl-2-oxopiperidine-3-carboxylate

Base Information

• Chemical Name: 2-(trimethylsilyl)ethyl 1-benzoyl-3-methyl-2-oxopiperidine-3-carboxylate
• CAS No.: 1596247-71-0
• Molecular Formula: C₁₉H₂₇NO₄Si
• Molecular Weight: 361.513
• Mol file: 1596247-71-0.mol

Synonyms:2-(trimethylsilyl)ethyl 1-benzoyl-3-methyl-2-oxopiperidine-3-carboxylate

Chemical Property of 2-(trimethylsilyl)ethyl 1-benzoyl-3-methyl-2-oxopiperidine-3-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(trimethylsilyl)ethyl 1-benzoyl-3-methyl-2-oxopiperidine-3-carboxylate

There total 1 articles about 2-(trimethylsilyl)ethyl 1-benzoyl-3-methyl-2-oxopiperidine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

1-benzoylpiperidin-2-one (4252-56-6) + 2-(trimethylsilyl)-ethoxycarbonyl chloride (20160-60-5) + methyl iodide (74-88-4) → 2-(trimethylsilyl)ethyl 1-benzoyl-3-methyl-2-oxopiperidine-3-carboxylate (1596247-71-0)

Guidance literature:

1-benzoylpiperidin-2-one; With lithium hexamethyldisilazane; In tetrahydrofuran; at 23 ℃; Cooling with acetone-dry ice; Inert atmosphere;

2-(trimethylsilyl)-ethoxycarbonyl chloride; In tetrahydrofuran; at 23 ℃; Inert atmosphere; Cooling with acetone-dry ice;

methyl iodide; In tetrahydrofuran; at 23 ℃; Cooling with ice; Inert atmosphere;

DOI:10.1021/ol500355z

Reference yield: 78.0%

allyl methyl carbonate (35466-83-2) + 2-(trimethylsilyl)ethyl 1-benzoyl-3-methyl-2-oxopiperidine-3-carboxylate (1596247-71-0) → (S)-3-allyl-1-benzoyl-3-methylpiperidin-2-one (1354568-45-8)

Guidance literature:

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; (S)-4-tert-butyl-2-[2-(diphenylphosphino)phenyl]-4,5-dihydro-1,3-oxazol; tetrabutylammonium triphenyldifluorosilicate; In tetrahydrofuran; at 25 ℃; enantioselective reaction; Inert atmosphere;

DOI:10.1021/ol500355z

upstream raw materials:

1-benzoylpiperidin-2-one

2-(trimethylsilyl)-ethoxycarbonyl chloride

methyl iodide

Downstream raw materials:

(S)-3-allyl-1-benzoyl-3-methylpiperidin-2-one