6-(3,4-dichlorophenyl) 1-[(methyloxy)methyl]-3-azabicyclo[4.1.0]heptane-3-carboxylate

Base Information

• Chemical Name: 6-(3,4-dichlorophenyl) 1-[(methyloxy)methyl]-3-azabicyclo[4.1.0]heptane-3-carboxylate
• CAS No.: 1013098-04-8
• Molecular Formula: C₁₄H₁₇Cl₂NO
• Molecular Weight: 286.201

Synonyms:6-(3,4-dichlorophenyl) 1-[(methyloxy)methyl]-3-azabicyclo[4.1.0]heptane-3-carboxylate

Chemical Property of 6-(3,4-dichlorophenyl) 1-[(methyloxy)methyl]-3-azabicyclo[4.1.0]heptane-3-carboxylate

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

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Technology Process of 6-(3,4-dichlorophenyl) 1-[(methyloxy)methyl]-3-azabicyclo[4.1.0]heptane-3-carboxylate

There total 14 articles about 6-(3,4-dichlorophenyl) 1-[(methyloxy)methyl]-3-azabicyclo[4.1.0]heptane-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

(1,1-dimethylethyl) (1S,6R)-6-(3,4-dichlorophenyl)-1-(methyloxymethyl)-3-azabicyclo[4.1.0]hept-4-ene-3-carboxylate (1013097-82-9) → 6-(3,4-dichlorophenyl) 1-[(methyloxy)methyl]-3-azabicyclo[4.1.0]heptane-3-carboxylate (1013098-04-8)

Guidance literature:

With triethylsilane; trifluoroacetic acid; In toluene; for 4h; Large scale reaction;

DOI:10.1021/op100139f

Reference yield: 91.0%

(+)-benzyl (1S,6R)-6-(3,4-dichlorophenyl)-1-(methoxymethyl)-3-azabicyclo[4.1.0]hept-4-ene-3-carboxylate (1313875-16-9) → 6-(3,4-dichlorophenyl) 1-[(methyloxy)methyl]-3-azabicyclo[4.1.0]heptane-3-carboxylate (1013098-04-8)

Guidance literature:

With hydrogen; sodium carbonate; palladium; In methanol; ethyl acetate; at 20 ℃; for 30h; under 760.051 Torr;

DOI:10.1002/chem.201101346

Reference yield:

1,1-dimethylethyl (1S,6R/1R,6S)-6-(3,4-dichlorophenyl)-1-(methoxymethyl)-3-azabicyclo[4.1.0]hept-4-ene-3-carboxylate → 6-(3,4-dichlorophenyl) 1-[(methyloxy)methyl]-3-azabicyclo[4.1.0]heptane-3-carboxylate (1013098-04-8)

Guidance literature:

With triethylsilane; trifluoroacetic acid; In toluene; at 20 ℃; for 48h; Product distribution / selectivity;

upstream raw materials:

1-(1,1-dimethylethyl) 3-ethyl 4-(3,4-dichlorophenyl)-1,2,5,6-tetrahydropyridine-1,3-dicarboxylate

(1,1-dimethylethyl) (1S,6R)-6-(3,4-dichlorophenyl)-1-(methyloxymethyl)-3-azabicyclo[4.1.0]hept-4-ene-3-carboxylate

1-tert-butyl 3-ethyl 4-oxopiperidine-1,3-dicarboxylate

1-(1,1-dimethylethyl) 3-ethyl 4-{[(trifluoromethyl)sulfonyl]oxy}-1,2,5,6-tetrahydropyridine-1,3-dicarboxylate

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