(R)-2-Propyl-piperidine-1-carboxylic acid (1S,2R,5S)-2-isopropyl-5-methyl-cyclohexyl ester

Base Information

• Chemical Name: (R)-2-Propyl-piperidine-1-carboxylic acid (1S,2R,5S)-2-isopropyl-5-methyl-cyclohexyl ester
• CAS No.: 226252-64-8
• Molecular Formula: C₁₉H₃₅NO₂
• Molecular Weight: 309.492

Synonyms:(R)-2-Propyl-piperidine-1-carboxylic acid (1S,2R,5S)-2-isopropyl-5-methyl-cyclohexyl ester

Chemical Property of (R)-2-Propyl-piperidine-1-carboxylic acid (1S,2R,5S)-2-isopropyl-5-methyl-cyclohexyl ester

Chemical Property:

Purity/Quality:

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Technology Process of (R)-2-Propyl-piperidine-1-carboxylic acid (1S,2R,5S)-2-isopropyl-5-methyl-cyclohexyl ester

There total 3 articles about (R)-2-Propyl-piperidine-1-carboxylic acid (1S,2R,5S)-2-isopropyl-5-methyl-cyclohexyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

(R)-7-Allyl-1,4-dithia-8-aza-spiro[4.5]decane-8-carboxylic acid (1S,2R,5S)-2-isopropyl-5-methyl-cyclohexyl ester → (R)-2-Propyl-piperidine-1-carboxylic acid (1S,2R,5S)-2-isopropyl-5-methyl-cyclohexyl ester (226252-64-8)

Guidance literature:

With hydrogen; nickel;

DOI:10.1055/s-1999-2623

Reference yield:

2-Allyl-4-hydroxy-5,6-dihydro-2H-pyridine-1,3-dicarboxylic acid 1-((1S,2R,5S)-2-isopropyl-5-methyl-cyclohexyl) ester 3-methyl ester → (R)-2-Propyl-piperidine-1-carboxylic acid (1S,2R,5S)-2-isopropyl-5-methyl-cyclohexyl ester (226252-64-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 80 percent / H₂O, NaCl / dimethylsulfoxide

2: 87 percent / BF₃*Et₂O

3: 90 percent / H₂ / Raney Ni

With boron trifluoride diethyl etherate; water; hydrogen; sodium chloride; nickel; In dimethyl sulfoxide;

DOI:10.1055/s-1999-2623

Reference yield:

2-Allyl-4-hydroxy-5,6-dihydro-2H-pyridine-1,3-dicarboxylic acid bis-((1S,2R,5S)-2-isopropyl-5-methyl-cyclohexyl) ester → (R)-2-Propyl-piperidine-1-carboxylic acid (1S,2R,5S)-2-isopropyl-5-methyl-cyclohexyl ester (226252-64-8)

Guidance literature:

Multi-step reaction with 4 steps

1: 74 percent / 140 °C

2: 80 percent / H₂O, NaCl / dimethylsulfoxide

3: 87 percent / BF₃*Et₂O

4: 90 percent / H₂ / Raney Ni

With boron trifluoride diethyl etherate; water; hydrogen; sodium chloride; nickel; In dimethyl sulfoxide;

DOI:10.1055/s-1999-2623

Downstream raw materials:

(-)-N-methylconiine

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