Technology Process of (2S)-benzyloxymethyl-5-methoxy-7-methyl-2-vinylchroman
There total 7 articles about (2S)-benzyloxymethyl-5-methoxy-7-methyl-2-vinylchroman which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
(2S)-(2-benzyloxymethyl-5-methoxy-7-methylchroman-2-yl)ethan-1-ol;
With
ortho-nitrophenyl selenocyanate; tributylphosphine;
In
tetrahydrofuran;
at 0 ℃;
for 4h;
With
sodium phosphate dibasic dihydrate; 3-chloro-benzenecarboperoxoic acid;
In
dichloromethane;
at -40 ℃;
for 4h;
With
diisopropylamine;
In
dichloromethane;
at -40 ℃;
for 15h;
DOI:10.1002/chem.201402495
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: platinum(IV) oxide; hydrogen / ethyl acetate / 2.25 h / 20 °C / 760.05 Torr
1.2: 1 h / 80 °C
2.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / 0 - 20 °C
2.2: 4 h / 0 - 20 °C
3.1: sodium ethanolate / N,N-dimethyl-formamide / 21 h / 120 °C
4.1: (S)-2,2’-bis-[(4S)-(-iso-butyl)-4,5-dihydrooxazol-2-yl]-1,1’-binaphthalene; palladium(II) trifluoroacetate; p-benzoquinone / methanol / 24 h / 20 °C
5.1: lithium aluminium tetrahydride / diethyl ether / 2 h / 0 - 20 °C
6.1: ortho-nitrophenyl selenocyanate; tributylphosphine / tetrahydrofuran / 4 h / 0 °C
6.2: 4 h / -40 °C
6.3: 15 h / -40 °C
With
platinum(IV) oxide; lithium aluminium tetrahydride; n-butyllithium; ortho-nitrophenyl selenocyanate; palladium(II) trifluoroacetate; tributylphosphine; (S)-2,2’-bis-[(4S)-(-iso-butyl)-4,5-dihydrooxazol-2-yl]-1,1’-binaphthalene; hydrogen; sodium ethanolate; p-benzoquinone;
In
tetrahydrofuran; methanol; diethyl ether; hexane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1002/chem.201402495
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / 0 - 20 °C
1.2: 4 h / 0 - 20 °C
2.1: sodium ethanolate / N,N-dimethyl-formamide / 21 h / 120 °C
3.1: (S)-2,2’-bis-[(4S)-(-iso-butyl)-4,5-dihydrooxazol-2-yl]-1,1’-binaphthalene; palladium(II) trifluoroacetate; p-benzoquinone / methanol / 24 h / 20 °C
4.1: lithium aluminium tetrahydride / diethyl ether / 2 h / 0 - 20 °C
5.1: ortho-nitrophenyl selenocyanate; tributylphosphine / tetrahydrofuran / 4 h / 0 °C
5.2: 4 h / -40 °C
5.3: 15 h / -40 °C
With
lithium aluminium tetrahydride; n-butyllithium; ortho-nitrophenyl selenocyanate; palladium(II) trifluoroacetate; tributylphosphine; (S)-2,2’-bis-[(4S)-(-iso-butyl)-4,5-dihydrooxazol-2-yl]-1,1’-binaphthalene; sodium ethanolate; p-benzoquinone;
In
tetrahydrofuran; methanol; diethyl ether; hexane; N,N-dimethyl-formamide;
DOI:10.1002/chem.201402495
