diethyl (1R*,3S*,3aR*,6aS*)-4,6-dioxo-5-phenyloctahydropyrrolo[3,4-c]pyrrole-1,3-dicarboxylate

Base Information

• Chemical Name: diethyl (1R*,3S*,3aR*,6aS*)-4,6-dioxo-5-phenyloctahydropyrrolo[3,4-c]pyrrole-1,3-dicarboxylate
• CAS No.: 1417822-84-4
• Molecular Formula: C₁₈H₂₀N₂O₆
• Molecular Weight: 360.367
• Mol file: 1417822-84-4.mol

Synonyms:diethyl (1R*,3S*,3aR*,6aS*)-4,6-dioxo-5-phenyloctahydropyrrolo[3,4-c]pyrrole-1,3-dicarboxylate

Chemical Property of diethyl (1R*,3S*,3aR*,6aS*)-4,6-dioxo-5-phenyloctahydropyrrolo[3,4-c]pyrrole-1,3-dicarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of diethyl (1R*,3S*,3aR*,6aS*)-4,6-dioxo-5-phenyloctahydropyrrolo[3,4-c]pyrrole-1,3-dicarboxylate

There total 2 articles about diethyl (1R*,3S*,3aR*,6aS*)-4,6-dioxo-5-phenyloctahydropyrrolo[3,4-c]pyrrole-1,3-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

glyoxylic acid ethyl ester (924-44-7) + N-phenyl-maleimide (941-69-5) + glycine ethyl ester hydrochloride (623-33-6) → diethyl (1R*,3S*,3aR*,6aS*)-4,6-dioxo-5-phenyloctahydropyrrolo[3,4-c]pyrrole-1,3-dicarboxylate (1417822-84-4)

Guidance literature:

With triethylamine; In toluene; at 110 ℃; for 24h; diastereoselective reaction;

DOI:10.1039/c2ob27072b

Reference yield:

glyoxylic acid ethyl ester (924-44-7) + N-phenyl-maleimide (941-69-5) + glycine ethyl ester hydrochloride (623-33-6) → diethyl (1R*,3S*,3aR*,6aS*)-4,6-dioxo-5-phenyloctahydropyrrolo[3,4-c]pyrrole-1,3-dicarboxylate (1417822-84-4) + diethyl (1R*,3R*,3aR*,6aS*)-4,6-dioxo-5-phenyloctahydropyrrolo[3,4-c]pyrrole-1,3-dicarboxylate

Guidance literature:

With silver(I) acetate; triethylamine; In toluene; at 25 ℃; for 24h; Overall yield = 85 %; diastereoselective reaction; Catalytic behavior; Darkness;

DOI:10.1016/j.tet.2015.09.039

upstream raw materials:

glyoxylic acid ethyl ester

N-phenyl-maleimide

glycine ethyl ester hydrochloride