8-Chloro-6-methoxyquinoline

Base Information

• Chemical Name: 8-Chloro-6-methoxyquinoline
• CAS No.: 796851-15-5
• Molecular Formula: C₁₀H₈ClNO
• Molecular Weight: 193.633
• Hs Code.: 2933499090
• Mol file: 796851-15-5.mol

Synonyms:8-Chloro-6-methoxyquinoline

Chemical Property of 8-Chloro-6-methoxyquinoline

Chemical Property:

• Vapor Pressure: 0.000784mmHg at 25°C
• Melting Point: 58-60 °C
• Refractive Index: 1.621
• Boiling Point: 316°C at 760 mmHg
• PKA: 2.38±0.20(Predicted)
• Flash Point: 144.9°C
• PSA: 22.12000
• Density: 1.267g/cm³
• LogP: 2.89680
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

8-Chloro-6-methoxyquinoline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 8-Chloro-6-methoxyquinoline

There total 4 articles about 8-Chloro-6-methoxyquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

8-Chlor-6-hydroxychinolin (18119-24-9) + methyl iodide (74-88-4) → 8-chloro-6-methoxyquinoline (796851-15-5)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃;

DOI:10.1021/jm1000908

Reference yield:

6-methoxyquinolin-8-amine (90-52-8) → 8-chloro-6-methoxyquinoline (796851-15-5)

Guidance literature:

With sulfuric acid; acetic acid; sodium nitrite; Diazotization_.anschliessenden Erwaermen mit einer Loesung von Kupfer(I)-chlorid in wss. Salzsaeure;

DOI:10.1021/ja01216a050

Reference yield:

4-Amino-3-chlorophenol hydrochloride (52671-64-4) → 8-chloro-6-methoxyquinoline (796851-15-5)

Guidance literature:

Multi-step reaction with 2 steps

1: sulfuric acid; boric acid; iron(II) sulfate / glycerol / 22 h / 0 - 150 °C

2: potassium carbonate / N,N-dimethyl-formamide / 20 °C

With sulfuric acid; boric acid; potassium carbonate; iron(II) sulfate; In N,N-dimethyl-formamide; glycerol;

upstream raw materials:

6-methoxyquinolin-8-amine

sulfuric acid

8-Chlor-6-hydroxychinolin

methyl iodide

Downstream raw materials:

8-Chlor-6-hydroxychinolin

6-methoxy-8-piperazinoquinoline

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