(1R,2R)-2-<<(tert-Butyldiphenylsilyl)oxy>methyl>-1-(hydroxymethyl)cyclopropane

Base Information

• Chemical Name: (1R,2R)-2-<<(tert-Butyldiphenylsilyl)oxy>methyl>-1-(hydroxymethyl)cyclopropane
• CAS No.: 154001-59-9
• Molecular Formula: C₂₁H₂₈O₂Si
• Molecular Weight: 340.538
• Mol file: 154001-59-9.mol

Synonyms:(1R,2R)-2-<<(tert-Butyldiphenylsilyl)oxy>methyl>-1-(hydroxymethyl)cyclopropane

Chemical Property of (1R,2R)-2-<<(tert-Butyldiphenylsilyl)oxy>methyl>-1-(hydroxymethyl)cyclopropane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1R,2R)-2-<<(tert-Butyldiphenylsilyl)oxy>methyl>-1-(hydroxymethyl)cyclopropane

There total 12 articles about (1R,2R)-2-<<(tert-Butyldiphenylsilyl)oxy>methyl>-1-(hydroxymethyl)cyclopropane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

(1R,2S)-2-(tert-butyldiphenylsilyloxy)methyl-1-hydroxymethyl-1-phenylsulfonylcyclopropane (408348-30-1) → (1R,2R)-2-<<(tert-Butyldiphenylsilyl)oxy>methyl>-1-(hydroxymethyl)cyclopropane (154001-59-9)

Guidance literature:

With magnesium; In methanol; at 50 ℃; for 24h;

DOI:10.1021/jo010852x

Reference yield: 18.0%

(1R,2S)-2-(tert-butyldiphenylsilyloxy)methyl-1-hydroxymethyl-1-phenylsulfonylcyclopropane (408348-30-1) → (1S,2R)-2-(tert-butyldiphenylsilyloxy)methyl-1-hydroxymethylcyclopropane (145920-52-1) + (1R,2R)-2-<<(tert-Butyldiphenylsilyl)oxy>methyl>-1-(hydroxymethyl)cyclopropane (154001-59-9)

Guidance literature:

With magnesium; In methanol; at 0 ℃; for 24h;

DOI:10.1021/jo010852x

Reference yield:

diiodomethane (75-11-6) + (E)-4-(tert-butyldiphenylsilyloxy)-2-buten-1-ol (92808-78-1) → (1R,2R)-2-<<(tert-Butyldiphenylsilyl)oxy>methyl>-1-(hydroxymethyl)cyclopropane (154001-59-9) + (1S,2S)-1-(tert-butyldiphenylsilanyloxy)methyl-2-hydroxymethylcyclopropane (408348-57-2)

Guidance literature:

With diethylzinc; diethylaluminium chloride; In hexane; dichloromethane; at 20 ℃; for 3h; Title compound not separated from byproducts.;

DOI:10.1002/anie.200705641

upstream raw materials:

(1R,2R)-2-(tert-butyldiphenylsilyloxy)methyl-1-formylcyclopropane

(1R,2S)-2-(tert-butyldiphenylsilyloxy)methyl-1-hydroxymethyl-1-phenylsulfonylcyclopropane

(1R,5S)-1-(phenylsulfonyl)-3-oxabicyclo[3.1.0]hexan-2-one

(1R,2S)-1,2-bis(hydroxymethyl)-1-phenylsulfonylcyclopropane

Downstream raw materials:

(1R,2R)-2-(tert-butyldiphenylsilyloxy)methyl-1-formylcyclopropane

((1R,2R)-2-Hydroxymethyl-cyclopropylmethyl)-carbamic acid tert-butyl ester

[(1R,2R)-2-(tert-Butyl-diphenyl-silanyloxymethyl)-cyclopropylmethyl]-carbamic acid tert-butyl ester

(1R,2R)-1-(Azidomethyl)-2-<<(tert-butyldiphenylsilyl)oxy>methyl>cyclopropane