3-(3-tert-butoxy-phenyl)-2-(4-nitro-phenoxycarbonylamino)-propionic acid tert-butyl ester

Base Information

Chemical Name:3-(3-tert-butoxy-phenyl)-2-(4-nitro-phenoxycarbonylamino)-propionic acid tert-butyl ester
CAS No.:327184-70-3
Molecular Formula:C₂₄H₃₀N₂O₇
Molecular Weight:458.511
Hs Code.:

3-(3-<i>tert</i>-butoxy-phenyl)-2-(4-nitro-phenoxycarbonylamino)-propionic acid <i>tert</i>-butyl ester

Synonyms:3-(3-tert-butoxy-phenyl)-2-(4-nitro-phenoxycarbonylamino)-propionic acid tert-butyl ester

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Chemical Property of 3-(3-tert-butoxy-phenyl)-2-(4-nitro-phenoxycarbonylamino)-propionic acid tert-butyl ester

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Technology Process of 3-(3-tert-butoxy-phenyl)-2-(4-nitro-phenoxycarbonylamino)-propionic acid tert-butyl ester

There total 5 articles about 3-(3-tert-butoxy-phenyl)-2-(4-nitro-phenoxycarbonylamino)-propionic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 7693-46-1
4-Nitrophenyl chloroformate

: 327184-68-9
2-amino-3-(3-tert-butoxy-phenyl)-propionic acid tert-butyl ester

: 327184-70-3
3-(3-tert-butoxy-phenyl)-2-(4-nitro-phenoxycarbonylamino)-propionic acid tert-butyl ester

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃;
DOI:10.1016/S0960-894X(00)00560-6

Reference yield:

: (3-tert-butoxy-phenyl)methyl bromide

: 327184-70-3
3-(3-tert-butoxy-phenyl)-2-(4-nitro-phenoxycarbonylamino)-propionic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: 70 percent / BuLi / -78 °C

2.1: 0.25M aq. HCl

2.2: 61 percent / 2M aq. Na₂CO₃ / tetrahydrofuran / 20 °C

3.1: 95 percent / LiOH*H₂O / ethanol

4.1: 52 percent / BF₃*Et₂O

5.1: 93 percent / H₂ / 10 percent Pd/C / 20 °C

6.1: 56 percent / Hunig's base / CH₂Cl₂ / 20 °C

With hydrogenchloride; lithium hydroxide; n-butyllithium; boron trifluoride diethyl etherate; hydrogen; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In ethanol; dichloromethane;
DOI:10.1016/S0960-894X(00)00560-6

Reference yield:

: (2S,5R)-2-(3-tert-Butoxy-benzyl)-5-isopropyl-3,6-dimethoxy-2,5-dihydro-pyrazine

: 327184-70-3
3-(3-tert-butoxy-phenyl)-2-(4-nitro-phenoxycarbonylamino)-propionic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: 0.25M aq. HCl

1.2: 61 percent / 2M aq. Na₂CO₃ / tetrahydrofuran / 20 °C

2.1: 95 percent / LiOH*H₂O / ethanol

3.1: 52 percent / BF₃*Et₂O

4.1: 93 percent / H₂ / 10 percent Pd/C / 20 °C

5.1: 56 percent / Hunig's base / CH₂Cl₂ / 20 °C

With hydrogenchloride; lithium hydroxide; boron trifluoride diethyl etherate; hydrogen; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In ethanol; dichloromethane;
DOI:10.1016/S0960-894X(00)00560-6