(S)-2-(2,3-bis(bis(cyclohexyl-1-d)amino)cyclopropenimine)-3-phenylpropan-1-ol hydrochloride

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Chemical Name:(S)-2-(2,3-bis(bis(cyclohexyl-1-d)amino)cyclopropenimine)-3-phenylpropan-1-ol hydrochloride
CAS No.:1620078-18-3
Molecular Formula:C₃₆H₅₅N₃O*ClH
Molecular Weight:586.281
Hs Code.:

Synonyms:(S)-2-(2,3-bis(bis(cyclohexyl-1-d)amino)cyclopropenimine)-3-phenylpropan-1-ol hydrochloride

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Chemical Property of (S)-2-(2,3-bis(bis(cyclohexyl-1-d)amino)cyclopropenimine)-3-phenylpropan-1-ol hydrochloride

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Technology Process of (S)-2-(2,3-bis(bis(cyclohexyl-1-d)amino)cyclopropenimine)-3-phenylpropan-1-ol hydrochloride

There total 7 articles about (S)-2-(2,3-bis(bis(cyclohexyl-1-d)amino)cyclopropenimine)-3-phenylpropan-1-ol hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 6262-42-6
1,2,3,3-tetrachlorocyclopropene

: 3182-95-4
L-Phenylalaninol

: d₂-dicyclohexylamine

: 1620078-18-3
(S)-2-(2,3-bis(bis(cyclohexyl-1-d)amino)cyclopropenimine)-3-phenylpropan-1-ol hydrochloride

Guidance literature:: 1,2,3,3-tetrachlorocyclopropene; d₂-dicyclohexylamine; With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 23 ℃;

L-Phenylalaninol; In dichloromethane; for 12h;

With hydrogenchloride; In dichloromethane;
DOI:10.1021/ja504532d

Reference yield:

: 108-94-1,11119-77-0,9003-41-2,9075-99-4
cyclohexanone

: 1620078-18-3
(S)-2-(2,3-bis(bis(cyclohexyl-1-d)amino)cyclopropenimine)-3-phenylpropan-1-ol hydrochloride

Guidance literature:: Multi-step reaction with 7 steps

1.1: dichloromethane / 23 °C / Molecular sieve

2.1: sodium borodeuteride / methanol / 1 h / 0 °C

3.1: hydrogen; palladium on activated charcoal; palladium(II) hydroxide / methanol / 72 h / 760.05 Torr

4.1: dichloromethane / 23 °C / Molecular sieve

5.1: sodium borodeuteride / methanol / 1 h / 0 °C

6.1: sodium hydroxide / dichloromethane

7.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 23 °C

7.2: 12 h

With sodium borodeuteride; palladium on activated charcoal; hydrogen; palladium(II) hydroxide; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In methanol; dichloromethane;
DOI:10.1021/ja504532d

Reference yield:

: 92475-62-2
<1-2H>cyclohexylamine

: 1620078-18-3
(S)-2-(2,3-bis(bis(cyclohexyl-1-d)amino)cyclopropenimine)-3-phenylpropan-1-ol hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1.1: dichloromethane / 23 °C / Molecular sieve

2.1: sodium borodeuteride / methanol / 1 h / 0 °C

3.1: sodium hydroxide / dichloromethane

4.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 23 °C

4.2: 12 h

With sodium borodeuteride; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In methanol; dichloromethane;
DOI:10.1021/ja504532d