92475-62-2

Upstream product

• 100-64-1 cyclohexanone-oxime 
• 4471-09-4 N-benzylcyclohexylimine 
• 1642811-75-3 N-benzylcyclohexan-1-d-1-amine 
• 108-94-1 cyclohexanone 

Downstream Products

• 92799-47-8 N-1D-Cyclohexyl-N-nitroso-acetamid 
• 95079-98-4 5-<2-(<1-2H>cyclohexyl)-2-azaethylidene>-2,2-dimethyl-1,3-dioxane-4,6-dione 
• 1359876-29-1 C₁₃H₁₇⁽²⁾HN₂S 
• 1620078-18-3 (S)-2-(2,3-bis(bis(cyclohexyl-1-d)amino)cyclopropenimine)-3-phenylpropan-1-ol hydrochloride 
• 1620082-52-1 (S)-2-(2,3-bis(bis(cyclohexyl-1-d)amino)cyclopropenimine)-3-phenylpropan-1-ol 

Relevant academic research and scientific papers

Synthesis of alpha-deuterium-labelled cyclohexylamine and its deamination by rabbit liver microsomes.

In order to investigate the isotope effect on the microsomal oxidative deamination of cyclohexylamine, alpha-deuterium(D)-labelled cyclohexylamine was synthesized. The deuterium labelling was found exclusively at the alpha-position with a purity of greate

Substituted pyrimidinetrione compound, composition containing same and application of substituted pyrimidinetrione compound

The invention provides a substituted pyrimidinetrione compound, a composition containing the same and application of the substituted pyrimidinetrione compound. The invention discloses the pyrimidinetrione compound as shown in formula (I) or the crystal form, pharmaceutically acceptable salt, prodrug, stereisomer, hydrate or solvent compound thereof. The pyrimidinetrione compound and the composition containing the same can be used for regulating hypoxia-inducible factors (HIF) and/or erythropoietin (EPO) and can be used for preparing medicine for regulating and controlling human body anemia.

Transition state analysis of enantioselective br?nsted base catalysis by chiral cyclopropenimines

Experimental 13C kinetic isotope effects have been used to interrogate the rate-limiting step of the Michael addition of glycinate imines to benzyl acrylate catalyzed by a chiral 2,3-bis(dicyclohexylamino) cyclopropenimine catalyst. The reaction is found to proceed via rate-limiting carbon-carbon bond formation. The origins of enantioselectivity and a key noncovalent CH?O interaction responsible for transition state organization are identified on the basis of density functional theory calculations and probed using experimental labeling studies. The resulting high-resolution experimental picture of the enantioselectivity-determining transition state is expected to guide new catalyst design and reaction development.

Tertiary amines as synthetic equivalents of vinyl cations: Zinc bromide promoted coupling of propargylamines with α-isocyanoacetamides to give 2,4,5-trisubstituted oxazoles initiated by an internal redox process

Crabee interrupted: Propargylamines 1 react with α-isocyanoacetamides 2 in the presence of zinc bromide to afford vinyl oxazoles 3. The transformation, wherein the propargylamine acts as a vinyl cation synthetic equivalent, involves a domino sequence incorporating a 1,5-hydride shift, intermolecular trapping/cyclization, and a 1,6-elimination (see scheme). Copyright

Regioselective ring expansion of 2,4-diiminoazetidines via cleavage of C-N and C(sp3)-H bonds: Efficient construction of 2,3- dihydropyrimidinesulfonamides

A highly regioselective base-mediated ring expansion of 2,4-diiminoazetidines via cleavage of C-N and C(sp3)-H bonds is achieved for the first time to afford efficiently 2,3- dihydropyrimidinesulfonamides. The mechanism of the ring expansion via tandem 4π electrocyclic ring-opening/1,5-H shift/6π electrocyclic ring-closing is well confirmed by the trapping experiments of two key intermediates and deuterium labeling studies.

The Formation of Enaminoenaminones from N-Alkylaminomethylene Derivatives of Meldrum's Acid

Gas-phase pyrolysis of aminomethylene derivatives of Meldrum's acid gives enaminoenaminones .Deuterium labelling stidies have shown that the mechanism involves tautomerism of the initial methyleneketene intermediate to an iminoketene,