ethyl (+)-(2S,3S)-8-chloro-2,3,4,5-tetrahydro-3-hydroxy-2-(4-methoxyphenyl)-4-oxo-1,5-benzothioazepin-5-acetate

Base Information

• Chemical Name: ethyl (+)-(2S,3S)-8-chloro-2,3,4,5-tetrahydro-3-hydroxy-2-(4-methoxyphenyl)-4-oxo-1,5-benzothioazepin-5-acetate
• CAS No.: 156415-89-3
• Molecular Formula: C₂₀H₂₀ClNO₅S
• Molecular Weight: 421.901

Synonyms:ethyl (+)-(2S,3S)-8-chloro-2,3,4,5-tetrahydro-3-hydroxy-2-(4-methoxyphenyl)-4-oxo-1,5-benzothioazepin-5-acetate

Chemical Property of ethyl (+)-(2S,3S)-8-chloro-2,3,4,5-tetrahydro-3-hydroxy-2-(4-methoxyphenyl)-4-oxo-1,5-benzothioazepin-5-acetate

Chemical Property:

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Technology Process of ethyl (+)-(2S,3S)-8-chloro-2,3,4,5-tetrahydro-3-hydroxy-2-(4-methoxyphenyl)-4-oxo-1,5-benzothioazepin-5-acetate

There total 1 articles about ethyl (+)-(2S,3S)-8-chloro-2,3,4,5-tetrahydro-3-hydroxy-2-(4-methoxyphenyl)-4-oxo-1,5-benzothioazepin-5-acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.5%

(+)-(2S,3S)-8-chloro-3-hydroxy-2-(4-methoxyphenyl)-2,3-dihydro-5H-1,5-benzothiazepin-4-one (96142-63-1) + ethyl bromoacetate (105-36-2) → ethyl (+)-(2S,3S)-8-chloro-2,3,4,5-tetrahydro-3-hydroxy-2-(4-methoxyphenyl)-4-oxo-1,5-benzothioazepin-5-acetate (156415-89-3)

Guidance literature:

With potassium carbonate; In acetone;

DOI:10.1248/cpb.42.167

Reference yield: 98.4%

ethyl (+)-(2S,3S)-8-chloro-2,3,4,5-tetrahydro-3-hydroxy-2-(4-methoxyphenyl)-4-oxo-1,5-benzothioazepin-5-acetate (156415-89-3) → (+)-(2S,3S)-8-chloro-2,3,4,5-tetrahydro-3-hydroxy-2-(4-methoxyphenyl)-4-oxo-1,5-benzothioazepin-5-acetic acid (148039-96-7)

Guidance literature:

With sodium hydroxide; In tetrahydrofuran; methanol;

DOI:10.1248/cpb.42.167

Reference yield:

ethyl (+)-(2S,3S)-8-chloro-2,3,4,5-tetrahydro-3-hydroxy-2-(4-methoxyphenyl)-4-oxo-1,5-benzothioazepin-5-acetate (156415-89-3) → (+)-(2S,3S)-8-chloro-2,3,4,5-tetrahydro-3-hydroxy-2-(4-hydroxyphenyl)-4-oxo-1,5-benzothioazepin-5-acetic acid (148039-98-9)

Guidance literature:

With boron tribromide; In dichloromethane;

DOI:10.1248/cpb.42.167

upstream raw materials:

(+)-(2S,3S)-8-chloro-3-hydroxy-2-(4-methoxyphenyl)-2,3-dihydro-5H-1,5-benzothiazepin-4-one

ethyl bromoacetate

Downstream raw materials:

(+)-(2S,3S)-8-chloro-2,3,4,5-tetrahydro-3-hydroxy-2-(4-hydroxyphenyl)-4-oxo-1,5-benzothioazepin-5-acetic acid

(+)-(2S,3S)-8-chloro-2,3,4,5-tetrahydro-3-hydroxy-2-(4-methoxyphenyl)-4-oxo-1,5-benzothioazepin-5-acetic acid

(+)-(2S,3S)-2-(4-benzyloxyphenyl)-8-chloro-2,3,4,5-tetrahydro-3-hydroxy-4-oxo-1,5-benzothioazepin-5-acetic acid

methyl (+)-(2S,3S)-2-(4-benzyloxyphenyl)-8-chloro-3-hydroxy-2,3,4,5-tetrahydro-4-oxo-1,5-benzothioazepin-5-acetate

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