(5-nitro-3-(5,6,7-trimethoxy-1H-indole-2-carbonyl)-2,3-dihydro-1H-benzo[e]indol-1-yl)methyl 4-methylbenzenesulfonate

Base Information

Chemical Name:(5-nitro-3-(5,6,7-trimethoxy-1H-indole-2-carbonyl)-2,3-dihydro-1H-benzo[e]indol-1-yl)methyl 4-methylbenzenesulfonate
CAS No.:1333242-23-1
Molecular Formula:C₃₂H₂₉N₃O₉S
Molecular Weight:631.663
Hs Code.:

Synonyms:(5-nitro-3-(5,6,7-trimethoxy-1H-indole-2-carbonyl)-2,3-dihydro-1H-benzo[e]indol-1-yl)methyl 4-methylbenzenesulfonate

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Chemical Property of (5-nitro-3-(5,6,7-trimethoxy-1H-indole-2-carbonyl)-2,3-dihydro-1H-benzo[e]indol-1-yl)methyl 4-methylbenzenesulfonate

Chemical Property:

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Technology Process of (5-nitro-3-(5,6,7-trimethoxy-1H-indole-2-carbonyl)-2,3-dihydro-1H-benzo[e]indol-1-yl)methyl 4-methylbenzenesulfonate

There total 4 articles about (5-nitro-3-(5,6,7-trimethoxy-1H-indole-2-carbonyl)-2,3-dihydro-1H-benzo[e]indol-1-yl)methyl 4-methylbenzenesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 1333242-48-0
(5-nitro-2,3-dihydro-1H-benzo[e]indol-1-yl)methyl 4-methylbenzenesulfonate

: 128781-07-7
5,6,7-trimethoxy-1H-indole-2-carboxylic acid

: 1333242-23-1
(5-nitro-3-(5,6,7-trimethoxy-1H-indole-2-carbonyl)-2,3-dihydro-1H-benzo[e]indol-1-yl)methyl 4-methylbenzenesulfonate

: 193225-65-9
1-(chloromethyl)-5-nitro-3-<(5,6,7-trimethoxyindol-2-yl)carbonyl>-1,2-dihydro-3H-benzindole

Guidance literature:: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl acetamide; at 20 ℃; for 2h;
DOI:10.1016/j.bmc.2011.06.073

Reference yield:

: 98-59-9
p-toluenesulfonyl chloride

: 1333242-23-1
(5-nitro-3-(5,6,7-trimethoxy-1H-indole-2-carbonyl)-2,3-dihydro-1H-benzo[e]indol-1-yl)methyl 4-methylbenzenesulfonate

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine / dichloromethane / 0 - 20 °C

2: hydrogenchloride / 1,4-dioxane / 10 - 20 °C

3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl acetamide / 2 h / 20 °C

With pyridine; hydrogenchloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In 1,4-dioxane; dichloromethane; N,N-dimethyl acetamide;
DOI:10.1016/j.bmc.2011.06.073

Reference yield:

: 193225-63-7
3-(tert-butoxycarbonyl)-1-(hydroxymethyl)-5-nitro-1,2-dihydro-3H-benzindole

: 1333242-23-1
(5-nitro-3-(5,6,7-trimethoxy-1H-indole-2-carbonyl)-2,3-dihydro-1H-benzo[e]indol-1-yl)methyl 4-methylbenzenesulfonate

: 193225-65-9
1-(chloromethyl)-5-nitro-3-<(5,6,7-trimethoxyindol-2-yl)carbonyl>-1,2-dihydro-3H-benzindole

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine / dichloromethane / 0 - 20 °C

2: hydrogenchloride / 1,4-dioxane / 10 - 20 °C

3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl acetamide / 2 h / 20 °C

With pyridine; hydrogenchloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In 1,4-dioxane; dichloromethane; N,N-dimethyl acetamide;
DOI:10.1016/j.bmc.2011.06.073