Chloro-acetic acid (2S,3S,4S,5R,6R)-2-(4-allyloxy-3-nitro-benzyloxy)-3,5-bis-benzyloxy-6-(tert-butyl-diphenyl-silanyloxymethyl)-tetrahydro-pyran-4-yl ester

Base Information

Chemical Name:Chloro-acetic acid (2S,3S,4S,5R,6R)-2-(4-allyloxy-3-nitro-benzyloxy)-3,5-bis-benzyloxy-6-(tert-butyl-diphenyl-silanyloxymethyl)-tetrahydro-pyran-4-yl ester
CAS No.:864776-77-2
Molecular Formula:C₄₈H₅₂ClNO₁₀Si
Molecular Weight:866.48
Hs Code.:

Chloro-acetic acid (2S,3S,4S,5R,6R)-2-(4-allyloxy-3-nitro-benzyloxy)-3,5-bis-benzyloxy-6-(tert-butyl-diphenyl-silanyloxymethyl)-tetrahydro-pyran-4-yl ester

Synonyms:Chloro-acetic acid (2S,3S,4S,5R,6R)-2-(4-allyloxy-3-nitro-benzyloxy)-3,5-bis-benzyloxy-6-(tert-butyl-diphenyl-silanyloxymethyl)-tetrahydro-pyran-4-yl ester

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Chemical Property of Chloro-acetic acid (2S,3S,4S,5R,6R)-2-(4-allyloxy-3-nitro-benzyloxy)-3,5-bis-benzyloxy-6-(tert-butyl-diphenyl-silanyloxymethyl)-tetrahydro-pyran-4-yl ester

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Technology Process of Chloro-acetic acid (2S,3S,4S,5R,6R)-2-(4-allyloxy-3-nitro-benzyloxy)-3,5-bis-benzyloxy-6-(tert-butyl-diphenyl-silanyloxymethyl)-tetrahydro-pyran-4-yl ester

There total 5 articles about Chloro-acetic acid (2S,3S,4S,5R,6R)-2-(4-allyloxy-3-nitro-benzyloxy)-3,5-bis-benzyloxy-6-(tert-butyl-diphenyl-silanyloxymethyl)-tetrahydro-pyran-4-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (2R,3S,4S,5S,6R)-3,5-Bis-benzyloxy-2-(tert-butyl-diphenyl-silanyloxymethyl)-6-phenylsulfanyl-tetrahydro-pyran-4-ol

: 864776-77-2
Chloro-acetic acid (2S,3S,4S,5R,6R)-2-(4-allyloxy-3-nitro-benzyloxy)-3,5-bis-benzyloxy-6-(tert-butyl-diphenyl-silanyloxymethyl)-tetrahydro-pyran-4-yl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 93 percent / pyridine / 1 h / 20 °C

2: 92 percent / 4 Angstroem molecular sieves; NIS; TfOH / CH₂Cl₂ / 4 - 20 °C

With pyridine; N-iodo-succinimide; trifluorormethanesulfonic acid; 4 A molecular sieve; In dichloromethane;
DOI:10.1002/anie.200500777

Reference yield:

: 3011-34-5
4-hydroxy-3-nitrobenzaldehyde

: 864776-77-2
Chloro-acetic acid (2S,3S,4S,5R,6R)-2-(4-allyloxy-3-nitro-benzyloxy)-3,5-bis-benzyloxy-6-(tert-butyl-diphenyl-silanyloxymethyl)-tetrahydro-pyran-4-yl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 99 percent / K₂CO₃ / dimethylformamide / 1 h / 50 °C

2: 89 percent / NaBH₄ / methanol; tetrahydrofuran / 0.08 h / 0 °C

3: 92 percent / 4 Angstroem molecular sieves; NIS; TfOH / CH₂Cl₂ / 4 - 20 °C

With sodium tetrahydroborate; N-iodo-succinimide; trifluorormethanesulfonic acid; 4 A molecular sieve; potassium carbonate; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/anie.200500777

Reference yield:

: 58479-61-1
tert-butylchlorodiphenylsilane

: 864776-77-2
Chloro-acetic acid (2S,3S,4S,5R,6R)-2-(4-allyloxy-3-nitro-benzyloxy)-3,5-bis-benzyloxy-6-(tert-butyl-diphenyl-silanyloxymethyl)-tetrahydro-pyran-4-yl ester

Guidance literature:: Multi-step reaction with 3 steps

1: Et₃N; DMAP / dimethylformamide / 12 h / 20 °C

2: 93 percent / pyridine / 1 h / 20 °C

3: 92 percent / 4 Angstroem molecular sieves; NIS; TfOH / CH₂Cl₂ / 4 - 20 °C

With pyridine; dmap; N-iodo-succinimide; trifluorormethanesulfonic acid; 4 A molecular sieve; triethylamine; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/anie.200500777