4-<2-<(2R,4R)-4-benzoyloxy-6-hydroxy-3,4,5,6-tetrahydro-2H-pyran-2-yl>-ethyl>-3-pyridine carboxamide

Base Information

Chemical Name:4-<2-<(2R,4R)-4-benzoyloxy-6-hydroxy-3,4,5,6-tetrahydro-2H-pyran-2-yl>-ethyl>-3-pyridine carboxamide
CAS No.:146431-55-2
Molecular Formula:C₂₀H₂₂N₂O₅
Molecular Weight:370.405
Hs Code.:

Synonyms:4-<2-<(2R,4R)-4-benzoyloxy-6-hydroxy-3,4,5,6-tetrahydro-2H-pyran-2-yl>-ethyl>-3-pyridine carboxamide

Suppliers and Price of 4-<2-<(2R,4R)-4-benzoyloxy-6-hydroxy-3,4,5,6-tetrahydro-2H-pyran-2-yl>-ethyl>-3-pyridine carboxamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 4-<2-<(2R,4R)-4-benzoyloxy-6-hydroxy-3,4,5,6-tetrahydro-2H-pyran-2-yl>-ethyl>-3-pyridine carboxamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 4-<2-<(2R,4R)-4-benzoyloxy-6-hydroxy-3,4,5,6-tetrahydro-2H-pyran-2-yl>-ethyl>-3-pyridine carboxamide

There total 8 articles about 4-<2-<(2R,4R)-4-benzoyloxy-6-hydroxy-3,4,5,6-tetrahydro-2H-pyran-2-yl>-ethyl>-3-pyridine carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 146431-54-1
4-<2-<(2R,4R)-4-benzoyloxy-6-methoxy-3,4,5,6-tetrahydro-2H-pyran-2-yl>-ethyl>-3-pyridine carboxamide

: 146431-55-2
4-<2-<(2R,4R)-4-benzoyloxy-6-hydroxy-3,4,5,6-tetrahydro-2H-pyran-2-yl>-ethyl>-3-pyridine carboxamide

Guidance literature:: With hydrogenchloride; In tetrahydrofuran; for 2h; Heating;
DOI:10.1016/S0040-4020(01)80508-1

Reference yield:

: 5444-01-9
3-cyano-4-methylpyridine

: 146431-55-2
4-<2-<(2R,4R)-4-benzoyloxy-6-hydroxy-3,4,5,6-tetrahydro-2H-pyran-2-yl>-ethyl>-3-pyridine carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1: 1) NaH / 1) DMSO, room temp., 15 min 2) DMSO, room temp., 20 min

2: 78 percent / H₂ / 10percent Pd/C / ethanol / 4 h

3: 75 percent / H₂ / 10percent Pd/C / ethanol / 4 h

4: 85 percent / triphenylphosphine, DEAD / tetrahydrofuran / 2 h

5: 90 percent / 1N aq. HCl / tetrahydrofuran / 2 h / Heating

With hydrogenchloride; hydrogen; sodium hydride; triphenylphosphine; diethylazodicarboxylate; palladium on activated charcoal; In tetrahydrofuran; ethanol;
DOI:10.1016/S0040-4020(01)80508-1

Reference yield:

: 95641-15-9
1,6-anhydro-3-O-benzyl-2,4-dideoxy-β-D-threo-hexopyranoside

: 146431-55-2
4-<2-<(2R,4R)-4-benzoyloxy-6-hydroxy-3,4,5,6-tetrahydro-2H-pyran-2-yl>-ethyl>-3-pyridine carboxamide

Guidance literature:: Multi-step reaction with 7 steps

1: 89 percent / amberlite IR H(+) / 12 h / 30 °C

2: 1) (COCl)2, DMSO, 2) NEt₃ / 1) CH₂Cl₂, -60 deg C, 15 min, 2) to room temp.

3: 1) NaH / 1) DMSO, room temp., 15 min 2) DMSO, room temp., 20 min

4: 78 percent / H₂ / 10percent Pd/C / ethanol / 4 h

5: 75 percent / H₂ / 10percent Pd/C / ethanol / 4 h

6: 85 percent / triphenylphosphine, DEAD / tetrahydrofuran / 2 h

7: 90 percent / 1N aq. HCl / tetrahydrofuran / 2 h / Heating

With hydrogenchloride; oxalyl dichloride; Amberlite IR H(+); hydrogen; sodium hydride; dimethyl sulfoxide; triethylamine; triphenylphosphine; diethylazodicarboxylate; palladium on activated charcoal; In tetrahydrofuran; ethanol;
DOI:10.1016/S0040-4020(01)80508-1