4-NITROPHENYL-4-MORPHOLINOPHOSPHONOCHLORIDATE

Base Information

• Chemical Name: 4-NITROPHENYL-4-MORPHOLINOPHOSPHONOCHLORIDATE
• CAS No.: 79838-05-4
• Molecular Formula: C10H12 Cl N2 O5 P
• Molecular Weight: 306.64
• Mol file: 79838-05-4.mol

Synonyms:4-Nitrophenyl4-morpholinylphosphonochloridate

Chemical Property of 4-NITROPHENYL-4-MORPHOLINOPHOSPHONOCHLORIDATE

Chemical Property:

• Boiling Point: 442.1±55.0 °C(Predicted)
• PKA: -7.54±0.20(Predicted)
• PSA: 94.40000
• Density: 1.49±0.1 g/cm3(Predicted)
• LogP: 3.11380

Purity/Quality:

4-NITROPHENYL MORPHOLINOPHOSPHONOCHLORIDATE 97.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): C
• Hazard Codes: C
• Statements: 20/21/22-34
• Safety Statements: 26-27-28-36/37/39-45

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-NITROPHENYL-4-MORPHOLINOPHOSPHONOCHLORIDATE

There total 1 articles about 4-NITROPHENYL-4-MORPHOLINOPHOSPHONOCHLORIDATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

morpholine (110-91-8,99108-56-2) + 1-dichlorophosphoryloxy-4-nitro-benzene (777-52-6) → 4-nitrophenyl-4-morpholinylphosphonochloridate (79838-05-4)

Guidance literature:

In diethyl ether; for 1h;

Reference yield: 90.0%

4-nitrophenyl-4-morpholinylphosphonochloridate (79838-05-4) + {(3aR,4R,6R,6aR)-2-Methoxy-6-[6-(4-methoxy-phenylamino)-purin-9-yl]-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl}-methanol → 2',3'-O-(methoxymethylene)-6-N-(p-anisoyl)adenosine 5'-O-(4-nitrophenyl 4-morpholinylphosphonate)

Guidance literature:

With 1-methyl-1H-imidazole; In acetonitrile; at 20 ℃; for 16h;

Reference yield: 87.0%

4-nitrophenyl-4-morpholinylphosphonochloridate (79838-05-4) + (2R,3R,4S,5R)-5-Hydroxymethyl-2-[6-(4-methoxy-phenylamino)-purin-9-yl]-4-(4-methoxy-tetrahydro-pyran-4-yloxy)-tetrahydro-furan-3-ol → 3'-O-(4-methoxytetrahydro-4-pyranyl)-6-N-(p-anisoyl)adenosine 5'-O-(4-nitrophenyl 4-morpholinylphosphonate)

Guidance literature:

With 1-methyl-1H-imidazole; In acetonitrile; for 6h;

upstream raw materials:

morpholine

1-dichlorophosphoryloxy-4-nitro-benzene

Downstream raw materials:

2'-O-(4-methoxytetrahydro-4-pyranyl)uridine 5'-O-(4-nitrophenyl 4-morpholinylphosphonate)

Morpholin-4-yl-phosphonic acid (2R,3R,4R,5R)-3-[(2-chloro-phenoxy)-hydroxy-phosphoryloxy]-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-(4-methoxy-tetrahydro-pyran-4-yloxy)-tetrahydro-furan-2-ylmethyl ester 4-nitro-phenyl ester

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