Morpholin-4-yl-phosphonic acid (2R,3R,4R,5R)-3-[(2-chloro-phenoxy)-hydroxy-phosphoryloxy]-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-(4-methoxy-tetrahydro-pyran-4-yloxy)-tetrahydro-furan-2-ylmethyl ester 4-nitro-phenyl ester

Base Information

Chemical Name:Morpholin-4-yl-phosphonic acid (2R,3R,4R,5R)-3-[(2-chloro-phenoxy)-hydroxy-phosphoryloxy]-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-(4-methoxy-tetrahydro-pyran-4-yloxy)-tetrahydro-furan-2-ylmethyl ester 4-nitro-phenyl ester
CAS No.:83894-26-2
Molecular Formula:C₃₁H₃₇ClN₄O₁₆P₂
Molecular Weight:819.053
Hs Code.:

Morpholin-4-yl-phosphonic acid (2R,3R,4R,5R)-3-[(2-chloro-phenoxy)-hydroxy-phosphoryloxy]-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-(4-methoxy-tetrahydro-pyran-4-yloxy)-tetrahydro-furan-2-ylmethyl ester 4-nitro-phenyl ester

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Chemical Property of Morpholin-4-yl-phosphonic acid (2R,3R,4R,5R)-3-[(2-chloro-phenoxy)-hydroxy-phosphoryloxy]-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-(4-methoxy-tetrahydro-pyran-4-yloxy)-tetrahydro-furan-2-ylmethyl ester 4-nitro-phenyl ester

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Technology Process of Morpholin-4-yl-phosphonic acid (2R,3R,4R,5R)-3-[(2-chloro-phenoxy)-hydroxy-phosphoryloxy]-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-(4-methoxy-tetrahydro-pyran-4-yloxy)-tetrahydro-furan-2-ylmethyl ester 4-nitro-phenyl ester

There total 5 articles about Morpholin-4-yl-phosphonic acid (2R,3R,4R,5R)-3-[(2-chloro-phenoxy)-hydroxy-phosphoryloxy]-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-(4-methoxy-tetrahydro-pyran-4-yloxy)-tetrahydro-furan-2-ylmethyl ester 4-nitro-phenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 777-52-6
1-dichlorophosphoryloxy-4-nitro-benzene

: 83894-26-2
Morpholin-4-yl-phosphonic acid (2R,3R,4R,5R)-3-[(2-chloro-phenoxy)-hydroxy-phosphoryloxy]-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-(4-methoxy-tetrahydro-pyran-4-yloxy)-tetrahydro-furan-2-ylmethyl ester 4-nitro-phenyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 86 percent / diethyl ether / 1 h

2: 42 percent / 1-methylimidazole / acetonitrile / 6 h

3: dioxane / 16 h / 20 °C

4: triethylammonium bicarbonate / H₂O; CHCl₃

With 1,4-dioxane; 1-methyl-1H-imidazole; triethylamine carbonate; In diethyl ether; chloroform; water; acetonitrile;

Reference yield:

: 72351-28-1
2-chlorophenyl phosphordi(1H-1-[1,2,4]triazolide)

: 83894-26-2
Morpholin-4-yl-phosphonic acid (2R,3R,4R,5R)-3-[(2-chloro-phenoxy)-hydroxy-phosphoryloxy]-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-(4-methoxy-tetrahydro-pyran-4-yloxy)-tetrahydro-furan-2-ylmethyl ester 4-nitro-phenyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: dioxane / 16 h / 20 °C

2: triethylammonium bicarbonate / H₂O; CHCl₃

With 1,4-dioxane; triethylamine carbonate; In chloroform; water;

Reference yield:

: 79838-05-4
4-nitrophenyl-4-morpholinylphosphonochloridate

: 83894-26-2
Morpholin-4-yl-phosphonic acid (2R,3R,4R,5R)-3-[(2-chloro-phenoxy)-hydroxy-phosphoryloxy]-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-(4-methoxy-tetrahydro-pyran-4-yloxy)-tetrahydro-furan-2-ylmethyl ester 4-nitro-phenyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 42 percent / 1-methylimidazole / acetonitrile / 6 h

2: dioxane / 16 h / 20 °C

3: triethylammonium bicarbonate / H₂O; CHCl₃

With 1,4-dioxane; 1-methyl-1H-imidazole; triethylamine carbonate; In chloroform; water; acetonitrile;