(2S)-4-(2,5-difluorophenyl)-N-[(4S,6R)-6-fluoro-1-methylazepan-4-yl]-2-(hydroxymethyl)-N-methyl-2-phenyl-2,5-dihydro-1H-pyrrole-1-carboxamide

Base Information

Chemical Name:(2S)-4-(2,5-difluorophenyl)-N-[(4S,6R)-6-fluoro-1-methylazepan-4-yl]-2-(hydroxymethyl)-N-methyl-2-phenyl-2,5-dihydro-1H-pyrrole-1-carboxamide
CAS No.:847027-70-7
Molecular Formula:C₂₆H₃₀F₃N₃O₂
Molecular Weight:473.538
Hs Code.:

Synonyms:(2S)-4-(2,5-difluorophenyl)-N-[(4S,6R)-6-fluoro-1-methylazepan-4-yl]-2-(hydroxymethyl)-N-methyl-2-phenyl-2,5-dihydro-1H-pyrrole-1-carboxamide

Suppliers and Price of (2S)-4-(2,5-difluorophenyl)-N-[(4S,6R)-6-fluoro-1-methylazepan-4-yl]-2-(hydroxymethyl)-N-methyl-2-phenyl-2,5-dihydro-1H-pyrrole-1-carboxamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (2S)-4-(2,5-difluorophenyl)-N-[(4S,6R)-6-fluoro-1-methylazepan-4-yl]-2-(hydroxymethyl)-N-methyl-2-phenyl-2,5-dihydro-1H-pyrrole-1-carboxamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2S)-4-(2,5-difluorophenyl)-N-[(4S,6R)-6-fluoro-1-methylazepan-4-yl]-2-(hydroxymethyl)-N-methyl-2-phenyl-2,5-dihydro-1H-pyrrole-1-carboxamide

There total 18 articles about (2S)-4-(2,5-difluorophenyl)-N-[(4S,6R)-6-fluoro-1-methylazepan-4-yl]-2-(hydroxymethyl)-N-methyl-2-phenyl-2,5-dihydro-1H-pyrrole-1-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: tert-butyl (6-fluoro-1-methylazepan-4-yl)methylcarbamate

: 845256-49-7
(2S)-2-({[tert-butyl(dimethyl)silyl]oxy}methyl)-4-(2,5-difluorophenyl)-2-phenyl-2,5-dihydro-1H-pyrrole-1-carbonyl chloride

: 847027-69-4
(2S)-4-(2,5-difluorophenyl)-N-[(4R,6S)-6-fluoro-1-methylazepan-4-yl]-2-(hydroxymethyl)-N-methyl-2-phenyl-2,5-dihydro-1H-pyrrole-1-carboxamide

: 847027-70-7
(2S)-4-(2,5-difluorophenyl)-N-[(4S,6R)-6-fluoro-1-methylazepan-4-yl]-2-(hydroxymethyl)-N-methyl-2-phenyl-2,5-dihydro-1H-pyrrole-1-carboxamide

Guidance literature:: tert-butyl (6-fluoro-1-methylazepan-4-yl)methylcarbamate; With hydrogenchloride; In ethyl acetate; at 20 ℃; for 1h;

(2S)-2-({[tert-butyl(dimethyl)silyl]oxy}methyl)-4-(2,5-difluorophenyl)-2-phenyl-2,5-dihydro-1H-pyrrole-1-carbonyl chloride; With dmap; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 50 ℃;

With trifluoroacetic acid; In tetrahydrofuran; at 20 ℃; for 1h;

Reference yield:

: 686320-23-0
4-Allyl-4-phenyl-1,3-oxazolidin-2-one

: 847027-69-4
(2S)-4-(2,5-difluorophenyl)-N-[(4R,6S)-6-fluoro-1-methylazepan-4-yl]-2-(hydroxymethyl)-N-methyl-2-phenyl-2,5-dihydro-1H-pyrrole-1-carboxamide

: 847027-70-7
(2S)-4-(2,5-difluorophenyl)-N-[(4S,6R)-6-fluoro-1-methylazepan-4-yl]-2-(hydroxymethyl)-N-methyl-2-phenyl-2,5-dihydro-1H-pyrrole-1-carboxamide

Guidance literature:: Multi-step reaction with 10 steps

1.1: sodium periodate / ruthenium trichloride / dichloromethane; water; acetonitrile / 5 h / 20 °C

1.2: 5 h

2.1: hydrogenchloride / 20 °C

3.1: sodium hydride / tetrahydrofuran / 0 - 20 °C

4.1: lithium hexamethyldisilazane / tetrahydrofuran / -78 - 20 °C

4.2: 24 h / 100 °C

5.1: sodium hexamethyldisilazane / tetrahydrofuran / 1.5 h / -78 - 0 °C

5.2: -78 - 20 °C

5.3: 3 h / 90 °C

6.1: sodium hydroxide; water / ethanol / 3 h / 60 °C

7.1: 1H-imidazole / dichloromethane

8.1: Resolution of racemate

9.1: triethylamine / tetrahydrofuran / 3 h / 0 - 20 °C

10.1: hydrogenchloride / ethyl acetate / 1 h / 20 °C

10.2: 50 °C

10.3: 1 h / 20 °C

With 1H-imidazole; hydrogenchloride; sodium hydroxide; sodium periodate; water; sodium hexamethyldisilazane; sodium hydride; triethylamine; lithium hexamethyldisilazane; ruthenium trichloride; In tetrahydrofuran; ethanol; dichloromethane; water; ethyl acetate; acetonitrile; 5.3: Suzuki Coupling;

Reference yield:

: 193421-73-7
α-allylphenylglycine ethyl ester

: 847027-69-4
(2S)-4-(2,5-difluorophenyl)-N-[(4R,6S)-6-fluoro-1-methylazepan-4-yl]-2-(hydroxymethyl)-N-methyl-2-phenyl-2,5-dihydro-1H-pyrrole-1-carboxamide

: 847027-70-7
(2S)-4-(2,5-difluorophenyl)-N-[(4S,6R)-6-fluoro-1-methylazepan-4-yl]-2-(hydroxymethyl)-N-methyl-2-phenyl-2,5-dihydro-1H-pyrrole-1-carboxamide

Guidance literature:: Multi-step reaction with 12 steps

1.1: lithium aluminium tetrahydride / diethyl ether / 20 °C

2.1: triethylamine / dichloromethane / 4 h / 0 - 20 °C

3.1: sodium periodate / ruthenium trichloride / dichloromethane; water; acetonitrile / 5 h / 20 °C

3.2: 5 h

4.1: hydrogenchloride / 20 °C

5.1: sodium hydride / tetrahydrofuran / 0 - 20 °C

6.1: lithium hexamethyldisilazane / tetrahydrofuran / -78 - 20 °C

6.2: 24 h / 100 °C

7.1: sodium hexamethyldisilazane / tetrahydrofuran / 1.5 h / -78 - 0 °C

7.2: -78 - 20 °C

7.3: 3 h / 90 °C

8.1: sodium hydroxide; water / ethanol / 3 h / 60 °C

9.1: 1H-imidazole / dichloromethane

10.1: Resolution of racemate

11.1: triethylamine / tetrahydrofuran / 3 h / 0 - 20 °C

12.1: hydrogenchloride / ethyl acetate / 1 h / 20 °C

12.2: 50 °C

12.3: 1 h / 20 °C

With 1H-imidazole; hydrogenchloride; sodium hydroxide; sodium periodate; lithium aluminium tetrahydride; water; sodium hexamethyldisilazane; sodium hydride; triethylamine; lithium hexamethyldisilazane; ruthenium trichloride; In tetrahydrofuran; diethyl ether; ethanol; dichloromethane; water; ethyl acetate; acetonitrile; 7.3: Suzuki Coupling;