N-(9-((6aS,8R,9R,9aR)-9-hydroxy-2,2,4,4-tetraisopropyltetrahydro-6H-furo[3,2-f][1,3,5,2,4]trioxadisilocin-8-yl)-9H-purin-6-yl)benzamide

Base Information

Chemical Name:N-(9-((6aS,8R,9R,9aR)-9-hydroxy-2,2,4,4-tetraisopropyltetrahydro-6H-furo[3,2-f][1,3,5,2,4]trioxadisilocin-8-yl)-9H-purin-6-yl)benzamide
CAS No.:1172994-44-3
Molecular Formula:C₂₉H₄₃N₅O₆Si₂
Molecular Weight:613.861
Hs Code.:

Synonyms:N-(9-((6aS,8R,9R,9aR)-9-hydroxy-2,2,4,4-tetraisopropyltetrahydro-6H-furo[3,2-f][1,3,5,2,4]trioxadisilocin-8-yl)-9H-purin-6-yl)benzamide

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Chemical Property of N-(9-((6aS,8R,9R,9aR)-9-hydroxy-2,2,4,4-tetraisopropyltetrahydro-6H-furo[3,2-f][1,3,5,2,4]trioxadisilocin-8-yl)-9H-purin-6-yl)benzamide

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Technology Process of N-(9-((6aS,8R,9R,9aR)-9-hydroxy-2,2,4,4-tetraisopropyltetrahydro-6H-furo[3,2-f][1,3,5,2,4]trioxadisilocin-8-yl)-9H-purin-6-yl)benzamide

There total 7 articles about N-(9-((6aS,8R,9R,9aR)-9-hydroxy-2,2,4,4-tetraisopropyltetrahydro-6H-furo[3,2-f][1,3,5,2,4]trioxadisilocin-8-yl)-9H-purin-6-yl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: (6aS,8R,9R,9aR)-8-(6-amino-9H-purin-9-yl)-2,2,4,4-tetraisopropyltetrahydro-6H-furo[3,2-f][1,3,5,2,4]trioxadisilocin-9-ol

: 98-88-4
benzoyl chloride

: 1172994-44-3
N-(9-((6aS,8R,9R,9aR)-9-hydroxy-2,2,4,4-tetraisopropyltetrahydro-6H-furo[3,2-f][1,3,5,2,4]trioxadisilocin-8-yl)-9H-purin-6-yl)benzamide

Guidance literature:: (6aS,8R,9R,9aR)-8-(6-amino-9H-purin-9-yl)-2,2,4,4-tetraisopropyltetrahydro-6H-furo[3,2-f][1,3,5,2,4]trioxadisilocin-9-ol; With chloro-trimethyl-silane; at 0 - 20 ℃; for 1h; Inert atmosphere;

benzoyl chloride; With pyridine; at 20 ℃; Inert atmosphere; Cooling with ice;

With ammonium hydroxide; at 0 ℃;

Reference yield: 81.0%

: 69304-37-6
1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane

: 1172994-42-1
9-(α-L-arabinofuranosyl)-6-N-benzoyladenine

: 1172994-44-3
N-(9-((6aS,8R,9R,9aR)-9-hydroxy-2,2,4,4-tetraisopropyltetrahydro-6H-furo[3,2-f][1,3,5,2,4]trioxadisilocin-8-yl)-9H-purin-6-yl)benzamide

Guidance literature:: With pyridine; at 20 ℃; for 5h; Inert atmosphere;
DOI:10.1039/b905019c

Reference yield:

: 13039-64-0
(2S,3R,4R)-2-(hydroxymethyl)-5-methoxytetrahydrofuran-3,4-diol

: 1172994-44-3
N-(9-((6aS,8R,9R,9aR)-9-hydroxy-2,2,4,4-tetraisopropyltetrahydro-6H-furo[3,2-f][1,3,5,2,4]trioxadisilocin-8-yl)-9H-purin-6-yl)benzamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: pyridine / 0 - 20 °C

2.1: sulfuric acid / ethyl acetate / 3 h / 20 °C

3.1: trimethylsilyl trifluoromethanesulfonate; N,O-bis-(trimethylsilyl)-acetamide / toluene; 1,2-dichloro-ethane / 80 °C / Cooling with ice

4.1: ammonia / methanol / 16 h / -20 - 45 °C / Sealed tube

5.1: pyridine / ethyl acetate; hexane / 2 h / 0 °C / Inert atmosphere; Cooling with ice

6.1: chloro-trimethyl-silane / 1 h / 0 - 20 °C / Inert atmosphere

6.2: 20 °C / Inert atmosphere; Cooling with ice

6.3: 0 °C

With pyridine; chloro-trimethyl-silane; N,O-bis-(trimethylsilyl)-acetamide; trimethylsilyl trifluoromethanesulfonate; sulfuric acid; ammonia; In methanol; hexane; ethyl acetate; 1,2-dichloro-ethane; toluene;