2-amino-6-benzylsulfanyl-4-isobutyl-N³,N⁵-di-m-tolyl-3,4-dihydropyridine-3,5-dicarboxamide

Base Information

• Chemical Name: 2-amino-6-benzylsulfanyl-4-isobutyl-N³,N⁵-di-m-tolyl-3,4-dihydropyridine-3,5-dicarboxamide
• CAS No.: 1453263-64-3
• Molecular Formula: C₃₂H₃₆N₄O₂S
• Molecular Weight: 540.729

Synonyms:2-amino-6-benzylsulfanyl-4-isobutyl-N³,N⁵-di-m-tolyl-3,4-dihydropyridine-3,5-dicarboxamide

Chemical Property of 2-amino-6-benzylsulfanyl-4-isobutyl-N³,N⁵-di-m-tolyl-3,4-dihydropyridine-3,5-dicarboxamide

Chemical Property:

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Technology Process of 2-amino-6-benzylsulfanyl-4-isobutyl-N³,N⁵-di-m-tolyl-3,4-dihydropyridine-3,5-dicarboxamide

There total 3 articles about 2-amino-6-benzylsulfanyl-4-isobutyl-N³,N⁵-di-m-tolyl-3,4-dihydropyridine-3,5-dicarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

6-amino-4-isobutyl-2-thioxo-N3,N5-di-m-tolyl-1,2,3,4-tetrahydropyridine-3,5-dicarboxamide (1453263-54-1) → 2-amino-6-benzylsulfanyl-4-isobutyl-N3,N5-di-m-tolyl-3,4-dihydropyridine-3,5-dicarboxamide (1453263-64-3)

Guidance literature:

6-amino-4-isobutyl-2-thioxo-N³,N⁵-di-m-tolyl-1,2,3,4-tetrahydropyridine-3,5-dicarboxamide; With potassium hydroxide; In ethanol; water; at 20 ℃; for 0.166667h;

benzyl halide; In ethanol; water; at 20 ℃; for 24h; regioselective reaction;

DOI:10.1134/S1070363213070153

Reference yield:

isovaleraldehyde (590-86-3) → 2-amino-6-benzylsulfanyl-4-isobutyl-N3,N5-di-m-tolyl-3,4-dihydropyridine-3,5-dicarboxamide (1453263-64-3)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium; ethanol / 0.17 h / 20 °C

2.1: sodium ethanolate / 48 h / 20 °C

3.1: potassium hydroxide / ethanol; water / 0.17 h / 20 °C

3.2: 24 h / 20 °C

With ethanol; sodium ethanolate; sodium; potassium hydroxide; In ethanol; water; 1.1: |Knoevenagel Condensation;

DOI:10.1134/S1070363213070153

Reference yield:

2-thiocarbamoyl-N-m-tolyl-acetamide (501037-55-4) → 2-amino-6-benzylsulfanyl-4-isobutyl-N3,N5-di-m-tolyl-3,4-dihydropyridine-3,5-dicarboxamide (1453263-64-3)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium; ethanol / 0.17 h / 20 °C

2.1: sodium ethanolate / 48 h / 20 °C

3.1: potassium hydroxide / ethanol; water / 0.17 h / 20 °C

3.2: 24 h / 20 °C

With ethanol; sodium ethanolate; sodium; potassium hydroxide; In ethanol; water; 1.1: |Knoevenagel Condensation;

DOI:10.1134/S1070363213070153

upstream raw materials:

6-amino-4-isobutyl-2-thioxo-N³,N⁵-di-m-tolyl-1,2,3,4-tetrahydropyridine-3,5-dicarboxamide

isovaleraldehyde

2-thiocarbamoyl-N-m-tolyl-acetamide

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