(4S,5S)-4,5-dihydro-2-(2'-bromophenyl)-4-(<(tert-butyl)dimethylsilyloxy>methyl)-5-phenyloxazole

Base Information

Chemical Name:(4S,5S)-4,5-dihydro-2-(2'-bromophenyl)-4-(<(tert-butyl)dimethylsilyloxy>methyl)-5-phenyloxazole
CAS No.:154701-62-9
Molecular Formula:C₂₂H₂₈BrNO₂Si
Molecular Weight:446.459
Hs Code.:

Synonyms:(4S,5S)-4,5-dihydro-2-(2'-bromophenyl)-4-(<(tert-butyl)dimethylsilyloxy>methyl)-5-phenyloxazole

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Chemical Property of (4S,5S)-4,5-dihydro-2-(2'-bromophenyl)-4-(<(tert-butyl)dimethylsilyloxy>methyl)-5-phenyloxazole

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Technology Process of (4S,5S)-4,5-dihydro-2-(2'-bromophenyl)-4-(<(tert-butyl)dimethylsilyloxy>methyl)-5-phenyloxazole

There total 3 articles about (4S,5S)-4,5-dihydro-2-(2'-bromophenyl)-4-(<(tert-butyl)dimethylsilyloxy>methyl)-5-phenyloxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 104410-90-4
tert-butyldimethylsilyl trifluoroacetate

: 77250-62-5
(4S,5S)-4,5-dihydro-2-(2'-bromophenyl)-4-(hydroxymethyl)-5-phenyloxazole

: 154701-62-9
(4S,5S)-4,5-dihydro-2-(2'-bromophenyl)-4-(<(tert-butyl)dimethylsilyloxy>methyl)-5-phenyloxazole

Guidance literature:: With 2,6-dimethylpyridine; In dichloromethane; for 1h; Ambient temperature;
DOI:10.1016/S0040-4020(01)89379-0

Reference yield:

: 2042-37-7
o-cyanobromobenzene

: 154701-62-9
(4S,5S)-4,5-dihydro-2-(2'-bromophenyl)-4-(<(tert-butyl)dimethylsilyloxy>methyl)-5-phenyloxazole

Guidance literature:: Multi-step reaction with 2 steps

1: 57 percent / ZnCl₂ / chlorobenzene / 24 h / Heating

2: 93 percent / 2,6-lutidine / CH₂Cl₂ / 1 h / Ambient temperature

With 2,6-dimethylpyridine; zinc(II) chloride; In dichloromethane; chlorobenzene;
DOI:10.1016/S0040-4020(01)89379-0

Reference yield:

: 28143-91-1
(1S,2S)-2-amino-1-phenyl-1,3-diol

: 154701-62-9
(4S,5S)-4,5-dihydro-2-(2'-bromophenyl)-4-(<(tert-butyl)dimethylsilyloxy>methyl)-5-phenyloxazole

Guidance literature:: Multi-step reaction with 2 steps

1: 57 percent / ZnCl₂ / chlorobenzene / 24 h / Heating

2: 93 percent / 2,6-lutidine / CH₂Cl₂ / 1 h / Ambient temperature

With 2,6-dimethylpyridine; zinc(II) chloride; In dichloromethane; chlorobenzene;
DOI:10.1016/S0040-4020(01)89379-0